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Chemistry Profile


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Julia Brumaghim

Chemistry

Professor

864-656-0481
Hunter Hall 301 [Lab]
Hunter Hall 344 [Lab]
Hunter Hall 401 [Lab]
Hunter Hall 481 [Office]

brumagh@clemson.edu
Website
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Educational Background

A.B., Chemistry, Harvard University, 1994
Ph.D., Inorganic chemistry, University of Illinois at Urbana-Champaign, 1999
NIH Postdoctoral Fellow, Bioinorganic chemistry, University of California at Berkeley, 1999-2001
Postdoctoral fellow, DNA damage and repair, University of California at Berkeley, 2001-2003

Profile/About Me

Dr. Brumaghim earned her Ph.D. in inorganic chemistry from the University of Illinois at Urbana-Champaign. She then completed an NIH post-doctoral fellowship with Dr. Ken Raymond in the Department of Chemistry at the University of California at Berkeley in bioinorganic chemistry, followed by a second post-doctoral appointment with Dr. Stuart Linn in the Department of Molecular and Cellular Biology in DNA damage and repair, also at Berkeley. At Clemson University, Dr. Brumaghim has examined the ability of a variety of antioxidant classes to prevent metal-mediated oxidative damage. This oxidative damage is responsible for cell death during oxidative stress and leads to a wide variety of pathologies, including cardiovascular disease, cancer, and neurodegenerative diseases. However, due to the lack of readily deployable tools to study such damage and a lack of understanding about cellular metal-based processes, metal-mediated oxidative DNA damage is often overlooked for other, easier-to-study pathways. Dr. Brumaghim has developed tools to quantify antioxidant prevention of metal-mediated oxidative damage, and has demonstrated the first quantitatively predictive, structure-activity relationships for a variety of different antioxidant classes. She has also extended this work to explore mechanisms of nanoparticle toxicity and the ability of antioxidants to prevent this, radiation damage due to reactive oxygen species, and mechanisms of antifungal drug resistance related to metal binding, reactive oxygen species generation, and DNA instability.

Research Interests

Metal-mediated DNA damage by reactive oxygen species, metal oxide nanoparticle generation of reactive oxygen species and toxicology, metal-binding drugs, radiation damage by reactive oxygen species

Honors and Awards

Clemson University Research, Scholarship and Artistic Achievement Award (2020)
Rising Star Award from the Women Chemists Committee of the American Chemical Society (2014)
Award for the Best Paper from A Young Investigator from the Journal of Inorganic Biochemistry and Elsevier Publishers (2008)
CAREER Award from the National Science Foundation (2006-2012)
ACS PROGRESS/Dreyfus Lectureship Award from the American Chemical Society and the Camille and Henry Dreyfus Foundation (2004-2005)

Links

Brumaghim Group Publications
Brumaghim Group Website
ResearchGate Profile