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Genetics and Biochemistry Profiles


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James Morris

Genetics and Biochemistry

Professor

864-656-0293
Life Sciences Building 249A [Office]

jmorri2@clemson.edu
Website

 

Educational Background

Post-doctoral, Fellow, Johns Hopkins SOM, 2002
Ph.D., Cellular Biology, University of Georgia, 1997
MS, Entomology, University of Georgia, 1992
BS, Biology, College of William and Mary, 1990

Profile/About Me

EPIC Faculty

Courses Taught

GEN3000: Introduction to Genetics for Non-majors

BCHM3050: Introduction to Biochemistry for Non-majors

GEN3020: Introduction to Genetics

GEN3020H: Introduction to Genetics Honors Course

GEN3030: Introduction to Genetics Laboratory

GEN4910: Directed Research in Genetics,

GEN4910H: Honors College course, Directed Research in Genetics.

BCHM4910: Directed Research in Biochemistry

BCHM4910H: Honors College course, Directed Research in Biochemistry

GEN/BCHM8200: Proteomics and Genomics

GEN/BCHM8900: Special Topics, “Molecular Pathogenesis”

GEN/BCHM8900: Special Topics, “Molecular Parasitology”

HON2060: "Pandemics: Pending extinction?"

BCHM4430: Molecular and Biochemical Basis for Disease

Selected Publications

Tillery, L, Barret, K, Goldstein, J, Lassner JW, Osterhout, B, Tran, NL, Xu, L, Young, r, Craig, IC, Dranow, DM, Abendroth, J, Delker, SL, Davies, DR, Mayclin, SJ, Calhoun, B, Bolejack, MJ, Staker, B, Subramanian, S, Phan, IQ, Lorimer, DD, Myler, PJ, Edwards, TE, Kyle, DE, Rice, CA, Morris, JC, Leahy, JW, Manetsch, R, Barrett, LK, Van Voorhis, W. Naegleria fowleri: protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba. (Accepted, PLoS ONE)

Khalifa, M, Di Genova, M, McAlpine, S, Rozema, S, Monaghan, N, Morris, J, Knoll, L, Golden, J. Dual stage picolinic acid derived inhibitors of Toxoplasma gondii (2020) ACS Medicinal Chemistry Letters 11, 12, 2382-2388. https://doi.org/10.1021/acsmedchemlett.0c00267

Phan, IQ, Rice, CA, Craig, J, Noorai, RE, McDonald, J, Subramanian, S, Tillery, L, Barrett, LK, Shnkar, V, Morris, JC, Van Voorhis, WC, Kyle, DE, Myler, PJ. The transcriptome of Balamuthia mandrillaris trophozoites for structure-based drug design. bioRxiv. doi: https;//doi.org/10.1101/2020.06.29.178905

Srivastava, S, Darling, J, Suryadi, J, Morris, J, Drew, M, Subramaniam, S. Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures. (2020) IUCrJ, 7, 453-461.

Voyton, C, Choi, J., Qiu, Y., Ackroyd, CP, Morris, MT, Morris, JC, Christensen, KA. A microfluidic-based microscopy platform for continuous interrogation of Trypanosoma brucei during environmental perturbation. (2019) Biochemistry, 58, 875-882.

Milanes, JE, Suryadi, J, Abendroth, J, Van Voorhis, WC, Barrett, KF, Dranow, DM, Phan, IQ, Patrick, SL, Rozema, SD, Khalifa, MM, Golden, JE, Morris, JC. Enzymatic and structural characterization of the Naegleria fowleri glucokinase. (2019) Antimicrobial Agents and Chemotherapy, 63, e02410-18; DOI: 10.1128/AAC.2410-18.

Qiu, Y, Milanes, JE, Jones, JA, Noorai, RE, Shankar, V, Morris, JC. Glucose signaling is important for nutrient adaptation during differentiation of pleomorphic African trypanosomes, (2018) mSphere https://doi.org/10.1128/mSphere.00366-18 (Commentary by Dr. Christine Clayton, mSphere DOI. 10:1128/mSphere.00533-18.)

Voyton, C, Morris, MT, Ackroyd, CP, Morris, JC, Christensen, KA. A FRET flow cytometry-based high throughput screening assay to identify disrupters of glucose levels in Trypanosoma brucei. (2018) ACS Infectious Diseases, 4 (7), 1058-1066.

Voyton, C, Qiu, Y, Morris, MT, Ackroyd, CP, Suryadi, J, Crowe, L, Morris, JC, Christensen, KA. A FRET flow cytometry method for monitoring cytosolic and glycosomal glucose in living kinetoplastid parasites, (2018) PLoS Neglected Tropical Diseases, 12, doi: 10.1371/journal.pntd.0006523.


Flaherty, DP, Harris, MT, Schroeder CE, Khan, H, Kahney, EW, Hackler, A, Patrick, SL, Weiner WS, Aubé J, Sharlow, ER, Morris, JC, Golden, JE. Optimization and evaluation of antiparasitic benzamidobenzoic acids as inhibitors of kinetoplastid hexokinase 1. (2017) ChemMedChem, 12, 1994-2005

Gordhan, HM, Milanes, JE, Qiu, Y, Patrick, SL, Golden, JE, Christensen, KA, Morris, JC, Whitehead, DC. A targeted delivery strategy for the development of potent trypanocides. (2017) Chemical Communications, 53, 8735 - 8738

Lin, S, Voyton, C, Morris, MT, Ackroyd, CP, Morris, JC, Christensen, KA. pH regulation in glycosomes of procyclic form Trypanosoma brucei. (2017) Journal of Biological Chemistry 292, 7795-7805.

Hackler, A, Patrick, SL, Kahney, EW, Flaherty, DP, Sharlow, ER, Morris, JC, Golden, JE.. Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids. (2017) Bioorganic & Medicinal Chemistry Letters 27, 755-758.

Gordhan, HM, Patrick, SL, Swasy, MI, Hackler, AL, Anayee, M, Golden, JE, Morris, JC, Whitehead, D. Evaluation of substituted ebselen derivatives as potential trypanocidal agents, (2017) Bioorganic & Medicinal Chemistry Letters 27, 537-541.

Qiu, Y, Patrick, SL, and Morris JC. Invited Review: Nutrient sensing in kinetoplastid parasites (2016). Advances in Medicine and Biology. Vol 105, 177-202.

Davis, MI, Patrick, SL, Blanding, WM, Dwivedi, V, Suryadi, J, Golden, JE, Coussens, NP, Lee, OW, Shen, M, Boxer, MB, Hall, MD, Sharlow, ER, Drew, ME, Morris JC. Identification of novel Plasmodium falciparum hexokinase inhibitors with anti-parasitic activity, (2016) Antimicrobial Agents and Chemotherapy 60, 6023-6033.

Links

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