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Genetics and Biochemistry Profiles


James Morris

Professor
Associate Chair
Genetics and Biochemistry Department

Office: 249 LSB
Phone: 864-656-0293
Email: jmorri2@clemson.edu
Personal Website: https://morrislab2020.wixsite.com/labinfo

 

 Educational Background

Post-doctoral Fellow
Johns Hopkins SOM 2002

Ph.D. Cellular Biology
University of Georgia 1997

MS Entomology
University of Georgia 1992

BS Biology
College of William and Mary 1990

 Courses Taught

GEN3000: Introduction to Genetics for Non-majors
BCHM3050: Introduction to Biochemistry for Non-majors
GEN3020: Introduction to Genetics
GEN3020H: Introduction to Genetics Honors Course
GEN3030: Introduction to Genetics Laboratory
GEN4910: Directed Research in Genetics,
GEN4910H: Honors College course, Directed Research in Genetics.
BCHM4910: Directed Research in Biochemistry
BCHM4910H: Honors College course, Directed Research in Biochemistry
GEN/BCHM8200: Proteomics and Genomics
GEN/BCHM8900: Special Topics, “Molecular Pathogenesis”
GEN/BCHM8900: Special Topics, “Molecular Parasitology”
HON2060: "Pandemics: Pending extinction?"
BCHM4430: Molecular and Biochemical Basis for Disease

 Profile

EPIC Faculty

 Extension and Outreach

Founding member of EPIC

 Publications

1. Voyton, C, Choi, J., Qiu, Y., Ackroyd, CP, Morris, MT, Morris, JC, Christensen, KA. A microfluidic-based microscopy platform for continuous interrogation of Trypanosoma brucei during environmental perturbation. (2019) Biochemistry, 58, 875-882.

2. Milanes, JE, Suryadi, J, Abendroth, J, Van Voorhis, WC, Barrett, KF, Dranow, DM, Phan, IQ, Patrick, SL, Rozema, SD, Khalifa, MM, Golden, JE, Morris, JC. Enzymatic and structural characterization of the Naegleria fowleri glucokinase. (2019) Antimicrobial Agents and Chemotherapy, 63, e02410-18; DOI: 10.1128/AAC.2410-18.

3. Qiu, Y, Milanes, JE, Jones, JA, Noorai, RE, Shankar, V, Morris, JC. Glucose signaling is important for nutrient adaptation during differentiation of pleomorphic African trypanosomes, (2018) mSphere DOI: 10:1128/mSphere.00366-18. (Commentary by Dr. Christine Clayton, mSphere DOI: 10:1128/mSphere.00533-18.)

4. Qiu, Y, Shankar, V, Noorai, RE, Yeung, N, McAlpine, SG, Morris, JC. Identification of a post-transcriptional regulatory element that responds to glucose in the African trypanosome, (Posted) https://www.biorxiv.org/content/early/2018/05/21/327346

5. Voyton, C, Morris, MT, Ackroyd, CP, Morris, JC, Christensen, KA. A FRET flow cytometry-based high throughput screening assay to identify disrupters of glucose levels in Trypanosoma brucei. (2018) ACS Infectious Diseases, 4 (7), 1058-1066.

6. Voyton, C, Qiu, Y, Morris, MT, Ackroyd, CP, Suryadi, J, Crowe, L, Morris, JC, Christensen, KA. A FRET flow cytometry method for monitoring cytosolic and glycosomal glucose in living kinetoplastid parasites, (2018) PLoS Neglected Tropical Diseases, 12, doi: 10.1371/journal.pntd.0006523.

7. Zeng, W, Sun L, Xiang Z, Li N, Zhang J, He Y, Li Q, Yang F, Song J, Morris J, Rosenthal BM, Sun L, Liu H, Yang Z. Morphological and molecular characteristics of Sarcocystis bertrami from horses and donkeys in China. (2018) Veterinary Parasitology, 252, 89-94.

8. Flaherty, DP, Harris, MT, Schroeder CE, Khan, H, Kahney, EW, Hackler, A, Patrick, SL, Weiner WS, Aubé J, Sharlow, ER, Morris, JC, Golden, JE. Optimization and evaluation of antiparasitic benzamidobenzoic acids as inhibitors of kinetoplastid hexokinase 1. (2017) ChemMedChem, 12, 1994-2005

9. Soe, TN, Wu, Y, Tun MW, Wu X, Ruan, Y, Win AYN, Nyunt, MH, Mon, NCN, Han, KT, Aye, KM Morris, J, Pincan, S, Yang, Z, Kyaw, MP, Cui, L. Genetic diversity of Plasmodium falciparum populations in southeast and western Myanmar. (2017) Parasites & Vectors, 10, 322

10. Gordhan, HM, Milanes, JE, Qiu, Y, Patrick, SL, Golden, JE, Christensen, KA, Morris, JC, Whitehead, DC. A targeted delivery strategy for the development of potent trypanocides. (2017) Chemical Communications, 53, 8735 - 8738

11. Lin, S, Voyton, C, Morris, MT, Ackroyd, CP, Morris, JC, Christensen, KA. pH regulation in glycosomes of procyclic form Trypanosoma brucei. (2017) Journal of Biological Chemistry 292, 7795-7805.

12. Hackler, A, Patrick, SL, Kahney, EW, Flaherty, DP, Sharlow, ER, Morris, JC, Golden, JE.. Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids. (2017) Bioorganic & Medicinal Chemistry Letters 27, 755-758.

13. Gordhan, HM, Patrick, SL, Swasy, MI, Hackler, AL, Anayee, M, Golden, JE, Morris, JC, Whitehead, D. Evaluation of substituted ebselen derivatives as potential trypanocidal agents, (2017) Bioorganic & Medicinal Chemistry Letters 27, 537-541.

14. Qiu, Y, Patrick, SL, and Morris JC. Invited Review: Nutrient sensing in kinetoplastid parasites (2016). Advances in Medicine and Biology. Vol 105, 177-202.

15. Davis, MI, Patrick, SL, Blanding, WM, Dwivedi, V, Suryadi, J, Golden, JE, Coussens, NP, Lee, OW, Shen, M, Boxer, MB, Hall, MD, Sharlow, ER, Drew, ME, Morris JC. Identification of novel Plasmodium falciparum hexokinase inhibitors with anti-parasitic activity, (2016) Antimicrobial Agents and Chemotherapy 60, 6023-6033.

16. Hu, Y, Zhou, G, Ruan, Y, Lee, M-C, Xu, X, Deng, S, Bai, Y, Zhang, J, Morris, J, Liu, H, Wang, Y, Fan, Q, Li, P, Wu, Y, Yang, Z, Yan, G, Cui, L. Seasonal dynamics and micro-geographical spatial heterogeneity of malaria along the China-Myanmar border, (2016) Acta Tropica 157, 12-19.

17. Liu, H, Feng, G, Zeng, W, Li, X, Bai, Y, Deng, S, Ruan, Y, Morris, J, Li, S, Yang, Z, Cuih, L. A more appropriate white blood cell count for estimating malaria parasite density in Plasmodium vivax patients in northeastern Myanmar. (2016) Acta Tropica 156, 152-156.

18. Hackler, AL, Yijian, Q, Patrick, SL, Lee, SH, Acosta-Serano, A, Morris, JC. Characterization of an African trypanosome mutant refractory to lectin-induced death. (2015) Biochemistry and Biophysical Reports 4, 33-38.

19. Harris, MT, Mitchell, WG, Morris, JC. Targeting protozoan parasite metabolism: glycolytic enzymes in the therapeutic crosshairs. (2014) Current Medicinal Chemistry 21, 1668-78.

20. Joice, AC, Harris, MT, Kahney, EK, Dodson, HC, Maselli, AG, Whitehead, DC, and Morris JC. Exploring the mode of action of ebselen in Trypanosoma brucei hexokinase inhibition. (2013) The International Journal for Parasitology: Drugs and Drug Resistance 3, 154-160. (*Selected as “Editor’s Choice”)

21. Bauer, ST, Morris, JC, Morris, MT. Environmentally-regulated glycosome protein composition in the African trypanosome. (2013) Eukaryotic Cell 12, 1072-1079.

22. Harris, MT, Walker, DM, Drew, ME, Mitchell, WG, Dao, K, Schroeder, CE, Flaherty, DP, Weiner, WS, Golden JE, and Morris, JC. Interrogating a Hexokinase-Selected Small Molecule Library for Inhibitors of Plasmodium falciparum Hexokinase. (2013) Antimicrobial Agents and Chemotherapy 57, 3731-3737.

23. Lin, S, Morris, MT, Ackroyd, CP, Morris, JC, Christensen, KA. Peptide targeted delivery of pH sensor for quantitative measurements of intraglycosomal pH in live Trypanosoma brucei. (2013) Biochemistry 52, 3629-3637.

24. Joice, AC, Lyda, TL, Sayce, AC, Verplaetse, E, Morris, MT, Michels, PAM, Robinson, DR, Morris, JC. Extra-glycosomal localization of Trypanosoma brucei Hexokinase 2. (2012) The International Journal for Parasitology 42,401-409. (*Selected as “Editor’s Choice”)

25. Sharlow E, Golden JE, Dodson H, Morris M, Hesser M, Lyda T, Leimgruber S, Schroeder CE, Flaherty DP, Weiner WS, Simpson D, Lazo JS, Aubé J, Morris JC. Identification of inhibitors of Trypanosoma brucei hexokinases. (2010, updated 2011) Probe Report from the NIH Molecular Libraries Program. National Center for Biotechnology Information.

26. Dodson, HC, Morris MT, Morris JC. Glycerol-3-phosphate alters Trypanosoma brucei hexokinase activity in response to environmental change. (2011) The Journal of Biological Chemistry 286, 33150-33157.

27. Coley, A, Dodson, H, Morris, M, Morris JC. Glycolysis in the African Trypanosome: Targeting Enzymes and their Subcellular Compartments for Therapeutic Development. (2011) Molecular Biology International, doi:10.4061/2011/123702.

28. Hesser, MW, Morris, JC, Gibbons, JR. Advances in recombinant gonadotropin production for use in bovine superovulation. (2011) Reproduction in Domestic Animals, doi: 10.1111/j.1439-0531.2011.01767.x.

29. Dodson, HC, Lyda TL, Chambers, JW, Morris MT, Christensen, KA, Morris JC. Quercetin, a fluorescent bioflavanoid, inhibits Trypanosoma brucei hexokinase 1. (2011) Experimental Parasitology 127, 423-8.

30. Sharlow, ER, Lyda, TA, Dodson, HC, Mustata, G, Morris, MT, Leimgruber, SS, Lee, K-H, Kashiwada, Y, Close, D, Lazo, JS, Morris JC. A target-based high throughput screen yields Trypanosoma burcei hexokinase small molecule inhibitors with antiparasitic activity. (2010) PLoS Neglected Tropical Diseases 4, e659.

31. Clemmens CS, Morris MT, Lyda TL, Acosta-Serrano, A, Morris JC. Trypanosoma brucei AMP-activated kinase subunit homologs influence surface molecule expression. (2009) Experimental Parasitology 123, 250-7.

32. Chambers, JW, Kearns, M, Morris MT, Morris JC. Assembly of heterohexameric trypanosome hexokinases reveals that hexokinase 2 is a regulable enzyme. (2008) The Journal of Biological Chemistry 283, 14963-70.

33. Wilson ME, Morris JC, Gibbons JR. Bioactive, bacterial-derived recombinant bovine follicle-stimulating hormone. (2008) Reproduction, Fertility and Development 21(1) 246-247.

34. Wang, X, Beckham, T, Morris, JC, Chen, F, and Gangemi, JD. Bioactivities of gossypol, 6-methoxygossypol, and 6,6’-dimethoxygossypol. (2008) The Journal of Agricultural and Food Chemistry 56, 4393-4398.

35. Chambers, JW, Fowler, ML, Morris MT, Morris JC. The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1. (2008) Molecular and Biochemical Parasitology 158, 202-7.

36. Chambers, JW, Morris, MT, Smith, KS and Morris, JC. Residues in an ATP binding domain influence sugar binding in a trypanosome hexokinase. (2008) Biochem Biophys Res Comm 365, 420-5.

 Links

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