Faculty Profiles

Jonathan Fogle

Faculty, Acting Department Chair

Office: Hendrix Student Center

Education and Professional Certifications

PhD in Immunology

North Carolina State University

Diplomate
American College of Veterinary Internal Medicine SAIM (Small Animal Internal Medicine)

Clinical Studies, ECFVG certification
Louisiana State University School of Veterinary Medicine

DVM, High Honors
Ross University School of Veterinary Medicine

B.S. in Veterinary Science
University of Arizona

Areas of Expertise

Allergy

Autoimmunity

Immune dysfunction

Select Publications

Nag M, Fogle JE, Pillay S, Del Prete GQ, De Paris K. Tissue-Specific DNA Methylation Changes in CD8+ T Cells During Chronic Simian Immunodeficiency Virus Infection of Infant Rhesus Macaques. Viruses. 2024 Nov 27;16(12):1839. doi: 10.3390/v16121839. PMID: 39772149; PMCID: PMC11680437.

Banovic, Frane; Pearson, Jason; Denley, Tara; Blubaugh, Amanda; Kim, Sujung Jun; Fogle, Jonathan E.; Leon, Renato; Goss, Caleb. Characterization of the pruritus responses and pruritic behaviors in an interleukin 31-induced canine model of pruritus.  Vet Dermatol. 2024 Jun;35(3):296-304. doi: 10.1111/vde.13231. Epub 2023 Dec 27. PMID: 38149639.

Banovic, Frane; Pearson, Jason; Denley, Tara; Blubaugh, Amanda; Kim, Sujung Jun; Fogle, Jonathan E.; Leon, Renato; Goss, Caleb. Establishment of intradermal canine IL-31-induced pruritus model to evaluate therapeutic candidates in atopic dermatitis.  Vet. Sci. 2023, 10, 329. https://doi.org/10.3390/vetsci10050329

Balko JA, Fogle C, Stuska SJ, Fogle JE, Posner LP.  Retrospective and prospective assessment of butorphanol, azaperone and medetomidine (BAM™) for immobilisation of feral horses (Equus ferus caballus). Equine Vet J. 2022 May;54(3):549-555. doi: 10.1111/evj.13490. 

Spiri AM, Novacco M, Meli ML, Stirn M, Riond B, Fogle JE, Boretti FS, Herbert I, Hosie MJ, Hofmann-Lehmann R.  Modified-Live Feline Calicivirus Vaccination Elicits Cellular Immunity against a Current Feline Calicivirus Field Strain in an Experimental Feline Challenge Study.
Viruses. 2021 Aug 31;13(9):1736. doi: 10.3390/v13091736.

Kick AR, Amaral AF, Frias-De-Diego A, Cortes LM, Fogle JE, Crisci E, Almond GW, Käser T.
The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus.
Front Immunol. 2021 Mar 9;12:637613. doi: 10.3389/fimmu.2021.637613. 

Fogle JE, Hudson LB, Thomson AE, Sherman BL, Gruen ME, Lascelles BD, Colby BM, Clary GP, Longo F, Meeker RB. Improved neurocognitive performance in FIV infected cats following treatment with the p75 neurotrophin receptor ligand LM11A-31" J Neurovirol. 2021 Apr;27(2):302-324. doi: 10.1007/s13365-021-00956-2. Epub 2021 Mar 4

Mowat FM, Avelino J, Bowyer A, Parslow V, Westermeyer HD, Foster ML, Fogle JE, Bizikova P. Detection of circulating anti-retinal antibodies in dogs with sudden acquired retinal degeneration syndrome using indirect immunofluorescence: a case-control study. Exp Eye Res. 2020 Apr; 193:107989. doi: 10.1016/j.exer.2020.107989. Epub 2020 Feb 29.

Kick AR, Amaral AF, Cortes LM, Fogle JE, Crisci E, Almond GW1, Käser T. The T-Cell Response to Type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV).  Viruses. 2019 Aug 29;11(9). pii: E796. doi: 10.3390/v11090796.

K. Meichner, T. Stokol, J. Tarigo, A. Avery, M. J. Burkhard, S. Comazzi, J. Fogle, D. Marks-
Stowe, B. Rütgen, D. Seelig, A. Wasserkrug-Naor, W. Vernau, D. Bienzle. Multicenter flow cytometry proficiency testing of canine blood and lymph node samples.  
Vet Clin Pathol. 2020 Jun;49(2):249-257. doi: 10.1111/vcp.12843. Epub 2020 Apr 4.

Tuohy JL, Somarelli JA, Borst LB, Eward WC, Lascelles BDX, Fogle JE. Immune dysregulation and osteosarcoma: Staphylococcus aureus downregulates TGF-β and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma. Vet Comp Oncol. 2019 Aug 17. doi: 10.1111/vco.12529. PMID: 31420936

Fogle JE, Scott JA, Almond GW.  Antibiotic Therapy Does Not Alter the Humoral Response to Vaccination for Porcine Circovirus 2 in Weaned Pigs. Vet Sci. 2019 May 30;6(2). pii: E51. doi: 10.3390/vetsci6020051.  PMID: 31151211

Tuohy J, Fogle JE, Petty C, Meichner K, Borst LB, Griffith E, Osbourne J, Lascelles BDX. Assessment of a novel nanoparticle hyperthermia therapy in a murine model of osteosarcoma. Vet Surg. 2018 Nov;47(8):1021-1030. doi: 10.1111/vsu.12959. Epub 2018 Oct 11. PMID: 30307042

Wang Y, Nag M, Tuohy J, DeParis K, Fogle JE. T regulatory cell induced Foxp3 binds the IL2, IFNγ, and TNFα promoters in virus-specific CD8+ T cells from feline immunodeficiency virus infected cats. AIDS Res Hum Retroviruses. 2018 Mar;34(3):269-276. doi:10.1089/AID.2017.0187.  Epub 2017 Nov 17.PMID: 29037051

Kennedy CJ, Thomson AE, Griffith EH, Fogle J, Lascelles BDX, Meeker RB, Sherman BL, Gruen ME.  Enrichment Preferences of FIV-Infected and Uninfected Laboratory-Housed Cats. Viruses. 2018 Jul 3;10(7). pii: E353. doi: 10.3390/v10070353.

Nag M, Wang Y, De Paris K, E Fogle J.  Histone Modulation Blocks Treg-Induced Foxp3 Binding to the IL-2 Promoter of Virus-Specific CD8⁺ T Cells from Feline Immunodeficiency Virus-Infected Cats. Viruses. 2018 May 27;10(6). pii: E287. doi: 10.3390/v10060287.

Wang Y, Nag M, Tuohy JL, Fogle JE.  Micro-RNA 10a is increased in feline T regulatory cells and increases Foxp3 protein expression following in vitro transfection.  Veterinary Sciences (4), 12, February 2017. doi:10.3390/vetsci4010012. 

Fogle J, Jacob M, Blikslager A, Edwards A, Wagner B, Dean K, Fogle C. Comparison of LPS and soluble CD14 measurement between clinically endotoxaemic and nonendotoxaemic horses. Equine Vet J. 2017 Mar;49(2):155-159. doi: 10.1111/evj.12582. Epub 2016 May 6.

Tuohy JL, Lascelles BDX, Griffith EH, Fogle JE. Canine osteosarcoma influences monocyte phenotype and chemotactic function. J Vet Intern Med, June, 2016 30(4): 1167–1178. DOI: 10.1111/jvim.13983 

Meichner K, Fogle J, English L, Suter SE. Expression of apoptosis-regulating proteins Bcl-2 and Bax lymph node aspirates in dogs with lymphoma.  J Vet Intern Med. J Vet Intern Med. 2016 May;30(3):819-26. doi: 10.1111/jvim.13937. Epub 2016 Mar 25. 

Fogle JE, Tarigo JL, Thalheim L, Williams LE, English LB, Suter SE. CD45+ and CD45- lymphocyte populations identified by flow cytometry from dogs with lymphoma exhibit similar morphology and the same clonal (B cell or T cell) lineage. Vet Immunol Immunopathol. 2015 Oct 22. pii: S0165-2427(15)30004-0. doi: 10.1016/j.vetimm.2015.10.004. [Epub ahead of print] PMID: 26553299

Hood SF, Thompson EM, Akaronu NO, Miller MM, Fogle JE.  Monocyte-derived dendritic cells from feline immunodeficiency virus positive cats are productively infected and maintain CD8+ T cell stimulatory capacity Int J Virol AIDS. April 2015; (2) 1 http://clinmedlibrary.com/articles/ijva/ijva-2-007.php?jid=ijva

Miller MM, Akaronu N, Thompson EM, Hood SF, Fogle JE. Modulating DNA methylation in activated CD8+ T cells inhibits Treg cell-induced binding of FoxP3 to the CD8+ T cell IL2 promoter. J Immunol. 2015 Feb 1;194(3):990-8. doi: 10.4049/jimmunol.1401762. Epub 2014 Dec 29. PMID:25548225

Miller MM, Petty CS, Tompkins MB, Fogle JE.  CD4+CD25+ T regulatory cells activated during Feline Immunodeficiency Virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ/ GARP-mediated mechanism.  Virol J. 2014 Jan 18;11:7. doi: 10.1186/1743-422X-11-7.
*Recognized as one of “The Best Immunology Papers of 2014” at the 2015 ACVIM Forum

Meng L, Tompkins MB, Miller MM, Fogle JE. Lentivirus-activated T regulatory cells suppress T helper cell IL2 production by inhibiting NFAT2 binding to the IL2 promoter. AIDS Res Hum Retroviruses. 2014 Jan;30(1):58-66 PMID: 23924068

Miller M.M., Thompson E. M., Suter S. E., Fogle J.E. CD8+ clonality is associated with prolonged acute plasma viremia and altered mRNA cytokine profiles during the course of Feline Immunodeficiency Virus infection. Vet Immunol Immunopathol. 2013 Apr 15;152(3-4):200-8.  PMID: 23332729

Sibley TA, Miller MM, Fogle JE.  Human intravenous immunoglobulin (hIVIG) inhibits anti-CD32 antibody binding to canine DH82 cells and canine monocytes in vitro. Vet Immunol Immunopathol. 2013 Feb 15;151(3-4):229-34. PMID: 23276750 

Thalheim LLN, Suter SE, Borst L, Fogle JE, Williams L.  Lymphoma immunophenotype of dogs determined by immunohistochemistry, flow cytometry, and polymerase chain reaction for antigen receptor rearrangements.  J Vet Intern Med. 2013 Nov-Dec;27(6):1509-16. doi: 10.1111/jvim.12185. Epub 2013 Sep 20. PMID:24112291 

Miller M.M., Fogle J.E., Tompkins M.B Infection with Feline Immunodeficiency Virus Directly Activates CD4+CD25+ T Regulatory Cells. Journal of Virology 2013. Aug;87(16):9373-8. 10.1128/JVI.00996-13 JVI.00996-13, PMID: 23760252 

Miller M.M., Fogle J.E., Tompkins M.B. Feline Glycoprotein A Repetitions Predominant (GARP) anchors TGFb on the surface of CD4+CD25+ regulatory T cells and mediates lentivirus induced T cell immunodeficiency. AIDS Res Hum Retroviruses. 2013 Apr;29(4):641-51. PMID: 23373523

Miller M.M., Fogle J.E. Administration of Fozivudine Tidoxil as a Single-Agent Therapeutic during Acute Feline Immunodeficiency Virus Infection Does Not Alter Chronic Infection. Viruses. 2012; 4(6):954-962.

Fogle, J.E., Tompkins, W.A., Campbell B., Sumner D., Tompkins, M.B. Fozivudine tidoxil as a single agent therapy reduces plasma and cell associated viremia during acute feline immunodeficiency virus infection. J Vet Intern Med Vol. 25 (3) May / June 2011.

Fogle, J.E., Tompkins, W.A., Tompkins, M.B. CD4+CD25+ T regulatory cells from FIV+ cats induce a unique anergic profile in CD8+ lymphocyte targets. Retrovirology 7:97 Nov 2010.

Fogle, J.E., Mexas, A.M., Tompkins, W.A., Tompkins, M.B. CD4+CD25+ T regulatory cells inhibit CD8+ IFN production during acute and chronic FIV infection utilizing a membrane TGFβ dependent mechanism. AIDS Res Hum Retroviruses., 26(2):201-16. Feb 2010.

Mexas AM, Fogle JE, Tompkins WA, Tompkins MB. CD4+CD25+ Regulatory T cells are Infected and Activated During Acute FIV Infection. Vet Immunol Immunopathol, 126(3-4) 2008.

Smithberg SR, Fogle JE, Mexas AM, Reckling SK, Lankford SM, Tompkins MB, and Dean GA.  In vivo depletion of CD4+CD25+ regulatory T cells in cats.  J Immunol Methods., Jan 2008 

Meichner, Kristina; Holland, Blaire; Durrant, Jessica; Grindem, Carol; Breuhaus, Babetta; Moore, Peter; Neel, Jennifer; Linder, Keith; Borst, Luke; Fogle, Jonathan; Tarigo, Jaime. Extreme Lymphocytosis with Myelomonocytic Morphology in a Horse with Diffuse Intermediate to Large B-Cell Lymphoma. Vet Clin Pathol. 2017 Mar;46(1):64-71. doi: 10.1111/vcp.12435. Epub 2016 Dec 21.

Long CT, Williams M, Savage M, Fogle JE, Hudson LB. Probable Primary Polydipsia in a Domestic Shorthair Cat. JFMS Open Rep. 2015 Dec 1;1(2):2055116915615370. doi: 10.1177/2055116915615370. eCollection 2015 Jul-Dec.

Garden OA, Kidd L, Mexas AM, Chang YM, Jeffery U, Blois SL, Fogle JE, MacNeill AL, Lubas G, Birkenheuer A, Buoncompagni S, Dandrieux JRS, Di Loria A, Fellman CL, Glanemann B, Goggs R, Granick JL, LeVine DN, Sharp CR, Smith-Carr S, Swann JW, Szladovits B. ACVIM consensus statement on the diagnosis of immune-mediated hemolytic anemia in dogs and cats. J Vet Intern Med. 2019 Feb 26. doi:10.1111/jvim.15441. [Epub ahead of print] PubMed PMID: 30806491.

Hedgespeth BA, Fogle JE. Canine parvovirus vaccination.  Today’s Veterinary Practice. March / April 2021.

Nag M, De Paris K, E Fogle J.  Epigenetic Modulation of CD8⁺ T Cell Function in Lentivirus Infections: A Review.  Viruses. 2018 Apr 28;10(5). pii: E227. doi: 10.3390/v10050227. 

Fogle, JE, Bissett, SA. Mucosal Immunity and Canine Idiopathic Enteropathies. Comp Cont Ed Pract Vet: Volume 29(5) May 2007.

Fogle, JE, Bissett, SA.  Cholangiohepatitis in Cats.  Standards of Care- Emerg Crit Care Med: Vol 7.4 May 2005. 

Fogle, JE. Pit Viper Envenomation in Dogs. Standards of Care- Emerg Crit Care Med: Vol 6.8 Sep 2004.

Fogle JE.  Polysystemic Autoinflammatory and autoimmune disease.  In Wiley’s Textbook of Clinical Immunology, 1St Ed. Garden and Kidd.

Fogle JE.  Immunodeficiencies.  In Ettinger’s Textbook of Veterinary Internal Medicine, 9th Ed. Ettinger, Feldmann, Cote, Elsevier, 2023.

Fogle JE.  Juvenile polyarteritis.  In Clinical Veterinary Advisor Dogs and Cats.  4th Ed. Etienne Cote. Elsevier, 2023

Fogle JE.  Neonatal Isoerythrolysis.  In Clinical Veterinary Advisor Dogs and Cats.  4th Ed. Etienne Cote. Elsevier, 2023

Tompkins WA, Tompkins MB, Mexas AM, Fogle JE. CD4+CD25+ Regulatory T Cells in Viral Infections.  In Regulatory T cells and Clinical Application.  Springer, 2008.

Lay Publications: 

1. Why Don’t Antibodies Guarantee Immunity? NCSU CVM Global Health Newsletter, Covid information, 2020.

2. Flow cytometry for the busy oncologist.  Veterinary Cancer Society Newsletter, 2011.