The mission of the Arthur M. Spiro Institute for Entrepreneurial Leadership is to provide an educational and research program in entrepreneurship that will contribute to the economic development of the region, state, and nation. The focus is on wealth creation through entrepreneurial activity. Specific objectives for the Arthur M. Spiro Institute for Entrepreneurial Leadership include:

• ^{To implement an undergraduate and graduate course of study in entrepreneurship that is interdisciplinary in scope and incorporates an organized executive-in-residence program involving successful entrepreneurs with students and faculty to enhance the classroom experience.}
• ^{To support research in the field of entrepreneurship and wealth creation}
• ^{To work with the Clemson University Research Foundation (CURF) and other organizations to enhance activities and linkages of students, faculty, and entrepreneurs.}