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Biological Sciences Profiles


Julia George

Associate Professor
Biological Sciences Department

Office: 231 Long Hall
Phone: 864-656-2328
Email: jgeorg4@clemson.edu

 

 Educational Background

Ph.D. Molecular Neurobiology
The Rockefeller University 1992

B.S. Biochemistry
Texas A&M University 1987

 Courses Taught

BIOL 4930 - Senior Seminar

 Publications

(since 2008)

Yip, P.K., Schmitzberger, M., Al-Hasan, M., George, J., Tripoliti, E., Michael-Titus, A.T., Clayton, D., and Priestley, J.V. (2020) Serotonin expression in the song circuitry of adult male zebra finches. Neuroscience 444:170-182.

George, J.M., Bell, Z.W., Condliffe, D., Dohrer, K., Abaurrea, T., Spencer, K., Leitao, A., Gahr, M., Hurd, P.J., Clayton, D.F. (2019) Acute social isolation alters neurogenomic state in songbird forebrain. Proceedings of the National Academy of Sciences (USA) https://doi.org/10.1073/pnas.1820841116

Bell ZW, Lovell P, Mello CV, Yip P, George JM, Clayton DF (2019) Urotensin-related gene transcripts mark developmental emergence of the male forebrain vocal control system in songbirds. Scientific Reports 9:816.

Ysselstein, D., Dehay, B., Costantino, I.M., McCabe, G.P., Frosch, M.P., George, J.M., Bezard, E., and Rochet, J.C. (2017) Endosulfine-alpha inhibits membrane-induced alpha-synuclein aggregation and protects against alpha-synuclein neurotoxicity, Acta Neuropathologica Communications 5:3.

Tuttle, M.D., Comellas, G., Nieuwkoop, A.J., Covell, D.J., Berthold, D.A., Kloepper, K.D., Courtney, J.M., Kim, J.K., Barclay, A.M., Kendall, A., Wan, W., Stubbs, G., Schwieters, C.D., Lee, V.M.Y., George, J.M., and Rienstra, C.M.(2016) Solid-state NMR structure of a pathogenic fibril of full-length human alpha-synuclein, Nature Structural and Molecular Biology 23:409-415.

Busch, D.J., Oliphint, P.A., Walsh, R.B., Banks, S.M.L., Woods, W.S., George, J.M., and Morgan, J.R. (2014) Acute increase of a-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation, Molecular Biology of the Cell 25(24), 3926-3941.

Yang, J.A., Lin, W., Woods, W.S., George, J.M., and Murphy, C.J. (2014) The Journal of Physical Chemistry B 118(13), 3559-3571.

Yang, J.A., Johnson, B., Wu, S., Woods, W.S., George, J.M., and Murphy, C.J. (2013) Study of wild-type a-synuclein binding and orientation on gold nanoparticles, Langmuir 29(14), 4603-4615.

Lemkau, L.R., Comellas, G., Lee, S.W., Rikardson, L.K., Woods, W.S., George, J.M., and Rienstra, C.M. (2013) Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K, PLoS One 8 (3), e49750.

Boassa, D., Berlanga, M., Yang, M.Y., Terada, M., Hu, J., Bushong, E.A., Hwang, M., Masliah, E., George, J.M., and Ellisman, M.H. (2013) Mapping the subcellular distribution of a-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson’s disease pathogenesis, Journal of Neuroscience 33(6), 2605-2615.

Lemkau, L.R., Comellas, G., Kloepper, K.D., Woods, W.S., George, J.M., and Rienstra, C.M. (2012) Mutant protein A30P ?-synuclein adopts wild-type fibril structure, despite slower fibrillation kinetics, Journal of Biological Chemistry 287(14), 11526-32.

Comellas, G., Lemkau, L.R., Zhou, D.H., George, J.M., and Rienstra, C.M. (2012) Structural intermediates during alpha-synuclein fibrillogenesis on phospholipid vesicles, Journal of the American Chemical Society 134, 5090-5099.

Comellas, G., Lemkau, L.R., Nieuwkoop, A.J., Kloepper, K.D., Ladror, D.T., Ebisu, R., Woods, W.S., Lipton, A.S., George, J.M., and Rienstra, C.M. (2011) Structured regions of ?-synuclein fibrils include the early-onset Parkinson's disease mutation sites, Journal of Molecular Biology 411(4), 881-895.

Yang, M.-L., Hasadsri, L, and George, J.M. (2010) Dynamic transport and localization of alpha-synuclein in primary hippocampal neurons, Molecular Neurodegeneration, 5(9).

Warren, W.C., Clayton, D.F., Ellegren, H., Arnold, A. P., Hillier, L. W., Kunstner, A., Searle, S., White, S., Vilella, A. J., Fairley, S., et al. (2010) The genome of a songbird, Nature 464, 757-762.

Hasadsri, L, Kreuter, J, Hattori, H, Iwasaki, T, and George, JM. (2009) Functional protein delivery into neurons using polymeric nanoparticles Journal of Biological Chemistry, 284(11):6972-6981.

Clayton, D.F., George, J.M., Mello, C.V. and Siepka, S.M. (2009) Conservation and expression of IQ-domain-containing calpacitin gene products (neuromodulin/GAP-43, Neurogranin/RC3) in the adult and developing oscine song control system, Developmental Neurobiology, 69(2-3):124-149.

Boettcher, J.M., Hartman, K.L., Ladror, D.T., Qi, Z., Woods, W.S., George, J.M., and Rienstra, C.M. (2008) Membrane-induced folding of the cAMP-regulated phosphoprotein endosulfine-alpha, Biochemistry 47(47), 12357-12364.

Replogle, K. L., Arnold, A. P., Ball, G. F., Band, M., Bensch, S., Brenowitz, E. A., Dong, S., Drnevich, J., Ferris, M., George, J. M., Gong, G., Hasselquist, D., Hernandez, A. G., Kim, R., Lewin, H. A., Liu, L., Lovell, P. V., Mello, C. V., Naurin, S., Rodriguez-Zas, S., Thimmapuram, J., Wade, J. and Clayton, D. F. (2008) The Songbird Neurogenomics (SoNG) Initiative: community-based tools and strategies for study of brain gene function and evolution. BMC Genomics 9, 131.

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