How to Submit a Protocol for Review
Submitting the Animal Use Protocol (AUP)
All research, teaching and testing activities involving live, vertebrate animals must be reviewed and approved by the Institutional Animal Care and Use Committee (IACUC) prior to initiation of the activities. In order to obtain approval for your teaching, testing, or research protocol, please follow these steps:
- Review the IACUC meeting schedule. When determining the start date for your project or teaching exercise, reference the IACUC meeting schedule for key dates and deadlines for protocol submissions during each meeting cycle. It may take as long as three (3) weeks to complete the IACUC approval process.
- Consult with the University/Attending Veterinarian during the development of your Animal Use Protocol (AUP) and prior to submitting the AUP. There is a checkbox documenting this consultation on the cover page of the AUP.
- Include information on external funding, if applicable, in the appropriate area (p.2) on the AUP.
- Complete applicable training per PHS Policy and The Animal Welfare Act. Training is offered online with the Collaborative Institutional Training Initiative (CITI) Program. Additionally, personnel with “significant animal contact” (defined as any contact with animals), must enroll in the Clemson University Medical Surveillance Program. For details, visit our Training page.
- Current literature searches (within 6 months) are required for all Animal Use Protocols which fall into Pain Categories D and E. Reduction, Refinement and Replacement (The 3-R's) must be part of the keywords used in the search. For assistance with literature searches and to obtain information on alternatives to painful procedures, contact a science librarian.
- Submit the Animal Use Protocol (AUP) form electronically as a Word file. The signed cover page should be submitted either as a high quality scanned PDF or mailed hard copy. Other supporting materials that must also be submitted include a flow chart and syllabus (if applicable).
- Protocols are approved for up to a three-year period. Annual reports are provided by the principal investigator and reviewed by the IACUC.
- If changes to approved protocols are needed, the principal investigator may submit an amendment form for review by the IACUC. Policy #13 describes changes to animal activities previously approved by the IACUC.
Qualifications of Personnel
Regulations in both the PHS Policy and The Animal Welfare Act require that Clemson University provide training for investigators, graduate students and technicians. Training is offered online with the Collaborative Institutional Training Initiative (CITI) Program. Additionally, personnel with “significant animal contact” (defined as any contact with animals), must enroll in the Clemson University Medical Surveillance Program.
The Animal Welfare Act places responsibility with the IACUC for determining qualifications of individuals involved in animal research, teaching and testing activities. Qualifications to perform specific procedures will be based on information provided in this section of the AUP.
Graduate students who plan to perform surgery, administer anesthesia or perform euthanasia must document adequate training prior to conducting these procedures. Investigators and research technicians who are not experienced with animal procedures required by the protocol must schedule individual training through the Office of Animal Resources. Veterinary technicians and research technicians skilled in performing specific procedures will provide training and provide the IACUC with an assessment of the individuals’ qualifications.
Investigators are responsible for ensuring that all their personnel are trained and that employees implement approved animal procedures.
Details for completing the CITI Program animal welfare training and enrolling in the Clemson University Medical Surveillance Program can be found on the Training page.
The Principal Investigator is responsible for ensuring all personnel involved in a proposed animal activity are trained, qualified, and approved by the IACUC to perform the procedures indicated on the qualifications section of the AUP.
For those not qualified to perform protocol specific procedures, the Office of Animal Resources is available to provide training (such as anesthesia, euthanasia, and other procedures) to all members of the research team.