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College of Behavioral, Social and Health Sciences

Faculty and Staff Profile

Janice Withycombe

PhD, RN, MN, CCRP, Associate Professor

Office: 255 Clemson University Nursing

Phone: (864) 720-2224


Vita: View

Educational Background

PhD Nursing
University of Arizona 2015

MN Nursing
University of South Carolina 1993

BSN Nursing
Clemson University 1987

Courses Taught

Evidence Based Practice
Palliative Care
Research Residency


As a pediatric oncology researcher, with a long history in maternal child nursing, I have a vested interest in helping to improve the lives of children with cancer. Research areas include physical activity, patient reported outcomes and patient/family education. Current research involves the use of metabolomics to explore relationships between oxidative stress, physical activity and patient symptoms in children receiving treatment for cancer. I strongly advocate for capturing the voice of children during cancer therapy and as such, I have a long history of working on studies related to instrument development and validation for pediatric Patient Reported Outcome (PRO) measures (specifically Pediatric PROMIS and Pediatric PRO-Common Terminology Criteria of Adverse Events). I am also very involved in nursing research and evidence based practice through the Children's Oncology Group and currently service as Chair for the Nursing Research committee within this organization.

Research Interests

Pediatric Oncology
Physical Activity
Patient/Family Education
Patient Reported Outcomes
Pediatric Oncology Summer Camps

Research Publications

Reeve, B.B., McFatrich, M., Mack, J. W., Maurer, S. H., Jacobs, S. S., Freyer, D. R., Withycombe, J. S., Baker, J. N., Castellino, S. N., Lin, L., Lucas, N. R., Hinds, P. S. (2020). Validity and Reliability of the Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events Measurement System. Journal of the National Cancer Institute. Published online first.

Reeve, B.B., McFatrich, M., Mack, J.W., Pinheiro, L. C., Jacobs, S. S., Baker, J. N., Withycombe, J. S., Lin, L., Mann, C., Villabroza, K. R., Hinds, P. S. (2020). Expanding construct validity of established and new PROMIS pediatric measures for children and adolescents receiving cancer treatment. Pediatric Blood & Cancer, 67(4), e28160. doi: 10.1002/pbc.28160

Mandrell, B., Withycombe, J.S. (2019). Symptom biomarkers for children receiving treatment for cancer: State of the science. Journal of Pediatric Oncology Nursing, 36(4), 280-286. doi: 10.1177/1043454219859233

Withycombe, J. S., Zupanec, S., Haugen, M., Macpherson, C., Landier, W. (2019). Consensus recommendations from the nursing state of the symptom science symposium: A Children’s Oncology Group report. Journal of Pediatric Oncology Nursing, 36(4):294-299. doi: 10.1177/1043454219854983

Withycombe, J.S., McFatrich, M., Pinheiro, L., Hinds, P. S., Keller, F. G., Baker, J. N., Mack, J W., Sung, L., Waldron, M., Reeve, B. B. (2019). The association of age, literacy and race on completing patient-reported outcome measures in pediatric oncology. Quality of Life Research, 28(7), 1793-1801. doi: 10.1007/s11136-019-02109-9

Withycombe, J. S., Alonzo, T. A., Wilkins-Sanchez, M. A., Adamson, P. C., Landier, W. (2019). The Children’s Oncology Group: Organizational structure, membership and institutional characteristics. Journal of Pediatric Oncology Nursing, 36(1), 24-34. doi: 10.1177/1043454218810141

Kelly, K.P., Withycombe, J., Stegenga, K., Rodgers, C.C. (2018). The why behind the questions: Question-asking in parents of children newly diagnosed with cancer - A report from the Children's Oncology Group. Journal of Pediatric Nursing, 43, 23-38. doi: 10.1016/j.pedn.2018.07.002

Withycombe, J. S., Baek, M. J., Jordan, D., Thomas, N., Hale, S. (2018). Pilot study evaluating physical activity and fatigue in adolescent oncology patients and survivors during summer camp. Journal of Adolescent and Young Adult Oncology, 7(2), 254-257. doi: 10.1089/jayao.2017.0074

Fernandez, C. V., Mullen, E., Chi, Y. Y., Ehrlich, P. F., Perlman, E. J., Kalapurakal, J., Khanna, G., Paulino, A. C., Hamilton, T. E., Gow, K. W., Tochner, Z., Hoffer, F., Withycombe, J., Shamberger, R. C., Kim, Y., Geller, J. I., Anderson, J. R., Grundy, P. E., Dome, J. S. (2018). Outcome and prognostic factors in stage III favorable histology Wilms Tumor (FHWT). A report from the Children’s Oncology Group study AREN0532. Journal of Clinical Oncology, 36(3), 254-261.

Pinheiro, L. C., McFatrich, M., Lucas, N. R., Walker, J. S., Withycombe, J. S., Hinds, P. S., Sung, L., Tomlinson, D., Freyer, D. R., Mack, J. W., Baker, J. N., Reeve, B. B. (2018). Child and Adolescent Self-Report Symptom Measurement in Pediatric Oncology Research: A Systematic Literature Review. Quality of Life Research, 27(2), 291-319.

Reeve, B.B., McFatrich, M., Pinheiro, L.C., Freyer, D.R., Basch, E.M., Baker, J.N., Withycombe, J.S., Sung, L., Mack, J.W., Waldron, M.K., Mowbray, C., Palma, D., Hinds. P.S. (2017).Cognitive interview-based validation of the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) in adolescents with cancer. Journal of Pain and Symptom Management. doi: 10.1016/j.jpainsymman.2016.11.006.

Stevens, K. R., Engh, E. P., Cooley, H. T., Conley, D. M., Cupit, T., D’Errico, E., DiNapoli, P., Fischer, J. L., Freed, R., Kotzer, A. M., Lindgren, C. L., Marino, M. A., Mestas, L, Perdue, J., Powers, R., Radovich, P., Rice, K., Riley, L. P., Rosenfeld, P., Roussel, L., Ryan-Wenger, N. A., Searle-Leach, L., Shonka, N. M., Smith, V. L., Sweatt, L., Townsend-Gervis, M., Wathen, E., Withycombe, J.S. (2017). Operational failures in frontline nursing. Research in Nursing & Health, 40, 197-205. doi: 10.1002/nur.21791

Reeve, B.B. , McFatrich, M., Pinheiro, L. C., Weaver, M. S., Sung, L., Withycombe, J. S., Baker, J. B., Mack, J., Waldron, M. K., Gibson, D., Tomlinson, D., Freyer, D., Mowbray, C., Jacobs, S., Palma, D., Martens, C., Gold, S., Jackson, K. D., Hinds, P. S. (2017). Eliciting the child’s voice in adverse event reporting in oncology trials: cognitive interview findings from the Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events initiative. Pediatric Blood and Cancer, 64(3). doi: 10.1002/pbc.26261. PMCID: 5301979

Rodgers, C., Kristen, S., Withycombe, J. S., Sachse, K., Kelly, K. P. (2016). Processing information after a child’s cancer diagnosis – How parents learn: A report from the Children’s Oncology Group. Journal of Pediatric Oncology Nursing, 33(6), 447-459. doi: 10.1177/1043454216668825

Landier, W., Ahern, J., Barakat, L.P., Bhatia, S., Bingen, K. M., Bondurant, P. G., Cohn, S. L, Dobrozsi, S. K., Haugen, M., Herring, R. A., Hooke, M., C., Martin, M., Murphy, K., Newman, A. R., Rodgers, C. C., Ruccione, K. S., Sullivan, J., Weiss, M., Withycombe, J., Hockenberry, M. (2016). Patient/Family education for newly diagnosed pediatric oncology patients: Consensus recommendations from a Children’s Oncology Group expert panel. Journal of Pediatric Oncology Nursing, 33, 422-431. doi: 10.1177/1043454216655983 PMID: 27385664

Withycombe, J. S., Andam-Mejia, R., Dwyer, A., Slaven, A., Windt, K., & Landier, W. (2016). A comprehensive survey of institutional patient/family educational practices for newly diagnosed pediatric oncology patients: A report from the Children’s Oncology Group. Journal of Pediatric Oncology Nursing, 33(6), 414-421. doi: 10.1177/1043454216652857

Hooke, M. C., Gilchrist, L., Tanner, L., Hart, N., & Withycombe, J. S. (2016). Use of a fitness tracker to promote physical activity in children with Acute Lymphoblastic Leukemia. Pediatric Blood and Cancer, 63, 684-689. doi:10.1002/pbc.25860

Weaver, M., Reeve B. B., Baker, J., Martens, C., McFatrich, M., Mowbray, C., Palma, D., Sung, L., Tomlinson, D., Withycombe, J., & Hinds, P. S. (2016). Concept elicitation phase for the pediatric Patient-Reported Outcome Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) measure development. Cancer, 122(1), 141-148. doi:10.1002/cncr.29702. PMCID: 4707103

Please reference full CV for publications prior to 2016.

Honors and Awards

2018 Early Career Researcher Award, Association of Pediatric Hematology Oncology Nurses

2018 Transdisciplinary Training in Energetics and Cancer (TREC) National Cancer Institute Fellow

2017 March of Dimes’ Pediatric Nurse of the Year for Georgia

2017 “High Five Faculty” Award (Excellence in Teaching based on Student Evaluations)

2017 Nell Hodgson Woodruff School of Nursing Excellence in Collaboration Award

2016 Children’s Oncology Group, Nursing Discipline Merit Award

College of Behavioral, Social and Health Sciences
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