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Genetics and Biochemistry Profiles


Trudy Mackay

Self Family Endowed Chair of Human Genetics
Professor, Department of Genetics and Biochemistry
Genetics and Biochemistry Department

Office: Self Regional Hall, 114 Gregor Mendel Circle, Gree
Phone: 864-889-0522
Email: tmackay@clemson.edu

 

 Educational Background

Ph.D. Genetics
University of Edinburgh 1979

M.Sc. Genetics
Dalhousie University 1975

B.Sc. (Hon) Biology
Dalhousie University 1974

 Courses Taught

I currently only teach research courses.

 Profile

I am a fellow of the American Association for the Advancement of Science, the American Academy of Arts and Sciences, the Royal Society of London and the National Academy of Sciences of the USA. I am the recipient of the Genetics Society of America Medal, the O. Max Gardner Award of the University of North Carolina, the North Carolina Award for Science, the Alexander Quarles Holladay Medal for Excellence from North Carolina State University, an honorary degree from the University of Buenos Aires, Argentina, and the Wolf Prize for Agriculture. I am on the editorial boards of PLoS Genetics, Genome Research, Proceedings of the National Academy of Sciences of the USA, Genes, Brain, Behavior, OpenBiology and G3. I currently serve on the NIH TWD-B study section for training grants, the Royal Society Newton Advanced Fellowship Committee and the Scientific Advisory Board of the Leiber Brain Institute.

 Research Interests

My general research goal is to understand the genetic and environmental factors affecting variation in quantitative (or complex) traits. This is necessary for risk modification of multifactorial human diseases, in theory for a more comprehensive view of the genetic processes underlying phenotypic evolution and in practice for improving production traits in domestic species. A comprehensive understanding of the genetic architecture of quantitative traits requires that we know (1) at what genetic loci segregating and mutational variation occurs; (2) the homozygous, heterozygous and epistatic effects, pleiotropic effects on other characters, including fitness; and environmental sensitivities of QTL alleles; and (3) the molecular genetic basis of quantitative variation in nature. This detailed characterization is only feasible in genetically tractable model organisms. My research focuses on Drosophila melanogaster, which has a wealth of genetic and genomic resources, and morphological, behavioral, physiological and life history characters spanning the gamut of fitness profiles. Since 75% of human disease genes have orthologs in D. melanogaster, it is also an excellent model for comparative analysis of human disease.

DNA polymorphisms do not directly affect variation in quantitative traits, but do so via networks of interacting transcripts, proteins, and metabolites. The field of systems genetics seeks to derive causal networks of these intermediate phenotypes that are accurate predictors of quantitative trait phenotypes. My laboratory has developed the Drosophila Genetic Reference Panel (DGRP), a community resource of inbred, sequenced inbred lines for whole genome association mapping and systems genetics analyses of quantitative traits. We are currently expanding the current DGRP of 205 lines to 2,000 lines and plan to phenotype them for all levels of intermediate phenotypes as well as organismal quantitative traits. We will use these data to derive regulatory networks de novo, based on multifactorial genetic perturbations, develop predictive models, and test model predictions using CRISPR/Cas9 germline gene editing. These projects are currently funded by three NIH grants.

Only 30% of patients (mostly children) with a genetic disease receive a diagnosis, even after sequencing exomes of patients and their parents. This may be because the patients have a disease-causing variant in a gene known to cause the disease, but it is of unknown significance; because they have a variant in a gene previously not known to cause disease, or because the disease-causing variants is regulatory in nature and not detectable by exome sequencing. Further, many known mutations cause a wide range of disease severity in patients, thought to be caused by naturally occurring variants elsewhere in the genome. We are using the Drosophila model to functionally characterize variants of unknown significance from clinical genome exome and whole genome sequencing and to identify candidate modifier genes for diseases with variable penetrance.

 Publications

Rollmann, S. M., Edwards, A. C., Yamamoto, A., Zwarts, L., Callaerts, P., Norga, K., Mackay, T. F. C. & Anholt, R. R. H. 2008. Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure. Genetics 179: 1327-1336. PMCID: PMC2475736

Sambandan, D., Carbone, M. A., Anholt, R. R. H. & Mackay, T. F. C. 2008. Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster. Genetics 179: 1079-1088. PMCID: PMC2429861

Yamamoto, A., Zwarts, L., Callaerts, P., Norga, K., Mackay, T. F. C. & Anholt, R. R. H. 2008. Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 105: 12393-12398. PMCID: PMC2527922

Ayroles, J. F., Carbone, M. A., Stone, E. A., Jordan, K. W., Lyman, R. F., Magwire, M. M., Rollmann, S. M., Duncan, L. H., Lawrence, F., Anholt, R. R. H. & Mackay, T. F. C. 2009. Systems genetics of complex traits in Drosophila melanogaster. Nat. Genet. 41: 299-307. PMCID: PMC2752214

Carbone, M. A., Ayroles, J. F., Yamamoto, A., Morozova, T. V., West, S. A., Magwire, M. M., Mackay, T. F. C. & Anholt, R. R. H. 2009. Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: Implications for glaucoma. PLoS ONE 4: e4216. PMCID: PMC2615221

Edwards, A. C. & Mackay, T. F. C. 2009. Quantitative trait loci for aggressive behavior in Drosophila melanogaster. Genetics 182: 889-897. PMCID: PMC2710167

Edwards, A. C., Ayroles, J. F., Stone, E. A., Carbone, M. A., Lyman, R. F. & Mackay, T. F. C. 2009. A transcriptional network associated with natural variation in Drosophila aggressive behavior. Genome Biology 10: R76. PMCID: PMC2728530

Edwards, A. C., Zwarts, L., Yamamoto, A. Callaerts, P. & Mackay, T. F. C. 2009. Mutations in many genes subtly affect aggressive behavior in Drosophila melanogaster. BMC Biology 7: 29. PMCID: PMC2707370

Flint, J. & Mackay, T. F. C. 2009. Genetic architecture of quantitative traits in mice, flies and humans. Genome Res. 19: 723-733. PMCID: PMC3647534

Harbison, S. T., Carbone, M. A., Ayroles, J. F., Stone, E. A., Lyman, R. F. & Mackay, T. F. C. 2009. Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep. Nat. Genet. 41: 371-375. PMCID: PMC2683981

Harbison, S. T., Mackay, T. F. C. & Anholt, R. R. H. 2009. Understanding the neurogenetics of sleep: Progress from Drosophila. Trends Genet. 25: 262-269.

Mackay, T. F. C. 2009. The genetic architecture of complex behaviors: Lessons from Drosophila. Genetica 136: 295-302.

Mackay, T. F. C., Stone, E. A. & Ayroles, J. F. 2009. The genetics of quantitative traits: Challenges and prospects. Nat. Rev. Genet. 10: 565-577.

Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., Cho, J. H., Guttmacher, A. E., Kong, A., Kruglyak, L., Mardis, E., Rotimi, C. N., Slatkin, M., Valle, D., Whittemore, A. S., Boehnke, M., Clark, A., Eichler, E. E., Gibson, G., Haines, J. L., Mackay, T. F. C., McCarroll, S. A. & Visscher, P. M. 2009. Finding the missing heritability of complex diseases. Nature 461: 747-753. PMCID: PMC2831613

Morozova, T. V., Ayroles, J. F., Jordan, K. W., Duncan, L. H., Carbone, M. A., Lyman, R. F., Stone, E. A., Govindaraju, D. R., Ellison, C. R., Mackay, T. F. C. and Anholt, R. R. H. 2009. Alcohol sensitivity in Drosophila: Translational potential of systems genetics. Genetics 83: 733-745. PMCID: PMC2766331

Yamamoto, A., Anholt, R. R. H. & Mackay, T. F. C. 2009. Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster. Genet. Res. 91: 373-382.

Zhou, S., Stone, E. A., Mackay, T. F. C. & Anholt, R. R. H. 2009. Plasticity of the chemoreceptor repertoire in Drosophila melanogaster. PLoS Genetics 5: e1000681. PMCID: PMC2750752

Arya, G. H., Weber, A. L., Wang, P., Magwire, M. M., Serrano Negron, Y. L., Mackay, T. F. C. & Anholt, R. R. H. 2010. Natural variation, functional pleiotropy and transcriptional contexts of odorant binding protein genes in Drosophila melanogaster. Genetics 186: 1475–1485. PMCID: PMC2998325

Clowers, K. J., Lyman. R. F., Mackay, T. F. C. & Morgan, T. J. 2010. Genetic variation in senescence marker protein-30 is associated with natural variation in cold tolerance in Drosophila. Genet. Res. 92: 103-113.

DesRoches, C. E., Busto, M., Riedl, C. A. L., Mackay, T. F. C. & Sokolowski, M. B. 2010. Quantitative trait locus mapping of geotaxis behavior in Drosophila melanogaster. Genet. Res. 92: 167-174.

Jumbo-Lucioni, P., Ayroles, J. F., Chambers, M. M., Jordan, K. W., Leips, J., Mackay, T. F. C & De Luca, M. 2010. Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster. BMC Genomics 11: 297. PMCID: PMC2880307

Mackay, T. F. C. 2010. Mutations and quantitative genetic variation: Lessons from Drosophila. Phil. Trans. Roy. Soc. B 365: 1229-1239.

Magwire, M. M., Yamamoto, A., Carbone, M. A., Roshina, N. V., Pasyukova, E. G., Morozova, T. V. & Mackay, T. F. C. 2010. Quantitative and molecular genetic analyses of mutations increasing Drosophila life span. PLoS Genetics 6: e1001037. PMCID: PMC2912381

Rollmann, S. M., Wang, P., Date, P., West, S. A., Mackay, T. F. C. & Anholt, R. R. H. 2010. Odorant receptor polymorphisms and natural variation in olfactory behavior in Drosophila melanogaster. Genetics 186: 687–697. PMCID: PMC2954467

Wang, P., Lyman, R. F., Mackay, T. F. C. & Anholt, R. R. H. 2010. Natural variation in odorant recognition among odorant binding proteins in Drosophila melanogaster. Genetics 184: 745-758. PMCID: PMC2845343

Zhou, S., Mackay, T. F. C & Anholt, R. R. H. 2010. Tuning the chemosensory window: A fly's perspective. Fly 4: 230-235.

Aitman, T. J., Boone, C., Churchill, G. A., Hengartner, M. O., Mackay, T. F. C. & Stemple, D. L. 2011. The future of model organisms in human disease research. Nat. Rev. Genet. 12: 575-582.

Ayroles, J. F., Laflamme, B. A., Stone, E. A., Wolfner, M. F. & Mackay, T. F. C. 2011. Functional genome annotation of Drosophila seminal fluid proteins using transcriptional genetic networks. Genet. Res. 93: 387-395.

Morozova, T. V., Mackay, T. F. C. & Anholt, R. R. H. 2011. Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. Genetics 187: 1193–1205. PMCID: PMC3070527

Zwarts, L., Magwire, M. M., Carbone, M. A., Yamamoto, A., Versteven, M., Anholt, R. R. H., Callaerts, P. & Mackay, T. F. C. 2011. Complex genetic architecture of Drosophila aggressive behavior. PNAS 108: 17070-17075. PMCID: PMC3193212

Anholt, R. R. H. & Mackay, T. F. C. 2012. Genetics of aggression. Annu. Rev. Genet. 46: 145-164.

Huang, W., Richards, S., Carbone, M. A., Zhu, D., Anholt, R. R. H., Ayroles, J. F., Duncan, L., Jordan, K. W., Lawrence, F., Magwire, M. M., Warner, C. B., Blankenburg, K., Han, Y., Javaid, M., Jayaseelan, J., Jhangiani, S. N., Muzny, D., Ongeri, F., Perales, L., Wu, Y.-Q., Zhang, Y., Zou, X., Stone, E. A., Gibbs, R. A. & Mackay, T. F. C. 2012. Epistasis dominates the genetic architecture of Drosophila quantitative traits. PNAS 109: 15553-15559. PMCID: PMC3465439

Jordan, K.W., Craver, K. L., Magwire, M. M., Cubilla, C. E., Mackay, T. F. C. & Anholt, R. R. H. 2012. Genome wide association for sensitivity to chronic oxidative stress in Drosophila melanogaster. PLoS ONE 7: e38722. PMCID: PMC3371005

Jumbo-Lucioni, P., Bu, S., Harbison, S. T., Slaughter, J. C., Mackay, T. F. C., Moellering, D. R. & De Luca. M. 2012. Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster. BMC Genomics 13: 659. PMCID: PMC3526424

Mackay, T. F. C., Richards, S., Stone, E. A., Barbadilla, A., Ayroles, J. F., Zhu, D., Casillas, S., Han, Y., Magwire, M. M., Cridland, J. M., Richardson, M. F., Anholt, R. R. H., Barrón, M., Bess, C., Blankenburg, K. P., Carbone, M. A., Castellano, D., Chaboub, L., Duncan, L., Harris, Z., Javaid, M., Jayaseelan, J. C., Jhangiani, S. N., Jordan, K. W., Lara-Garduno, F., Lawrence, F., Lee, S. L., Librado, P., Linheiro, R. S., Lyman, R. F., Mackey, A. J., Munidasa, M., Muzny, D. M., Nazareth, L., Newsham, I., Perales, L., Pu, L.-L., Qu, J., Ràmia, M., Reid, J. G., Rollmann, S. M., Rozas, J., Saada, N., Turlapati, L., Worley, K. C., Wu, Y.-Q., Yamamoto, A., Zhu, Y., Bergman, C. M., Thornton, K. R., Mittelman, D. & Gibbs, R. A. 2012. The Drosophila melanogaster Genetic Reference Panel. Nature 482: 173-178. PMCID: PMC3683990

Massouras, A., Waszak, S. M., Albarca, M., Hens, K., Ayroles, J. F., Dermitzakis, E. T., Stone, E. A., Mackay, T. F. C. & Deplancke, B. 2012. The cis-regulatory architecture of gene expression variation in Drosophila. PLoS Genetics 8: e1003055. PMCID: PMC3499359

Morozova, T. V., Goldman, D. Mackay, T. F. C. & Anholt, R. R. H. 2012. The genetic basis of alcohol consumption: Multiple phenotypes, many genes, complex networks. Genome Biology 13: 239. PMCID: PMC3334563

Ober, U., Ayroles, J. F., Stone, E. A., Richards, S., Gibbs, R. A., Stricker, C., Gianola, D., Schlather, M., Mackay, T. F. C. & Simianer, H. 2012. Using whole genome sequence data to predict phenotypic traits in Drosophila melanogaster. PLoS Genetics 8: e1002685. PMCID: PMC3342952

Swarup, S. Harbison, S. T., Hahn, L. E., Morozova, T. V., Yamamoto, A., Mackay, T. F. C. & Anholt, R. R. H. 2012. Extensive epistasis for olfactory behavior, sleep and waking activity in Drosophila melanogaster. Genet. Res. 94: 9-20. PMCID: PMC3283907

Weber, A. L., Khan, G. F., Magwire, M. M., Tabor, C. L., Mackay, T. F. C. & Anholt, R. R. H. 2012. Genome-wide association for oxidative stress resistance in Drosophila melanogaster. PLoS ONE 7: e34745. PMCID: PMC3319608

Zhou, S., Campbell, T. G., Mackay, T. F. C. & Anholt, R. R. H. 2012. Phenotypic plasticity of the Drosophila transcriptome. PLoS Genetics 3: e11002593. PMCID: PMC33154

Harbison, S. T., McCoy, L. J. & Mackay, T. F. C. 2013. Genome-wide association study of sleep in Drosophila melanogaster. BMC Genomics 14: 281. PMCID: PMC3644253

Swarup, S., Huang, W., Mackay, T. F. C & Anholt, R. R. H. 2013. Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior. Proc. Natl. Acad. Sci. USA. 110:1017-1022. PMCID: PMC3549129

Wilson, R. H., Lai, C. Q., Lyman, R. F. & Mackay, T. F. C. 2013. Quantitative genetics and genomics of postponed senescence in Drosophila. Mech. Ageing Dev. 134: 79-88. PMCID: PMC3918434

Anholt, R. R. H. & Mackay, T. F. C. 2014. Dissecting the genetic architecture of behavior in Drosophila melanogaster. Curr. Opinion Behav. Sci., in press.

Ellis, L. L., Huang, W., Quinn, A. M., Ahuja, A., Alfrejd, B., Gomez, F. E., Hjelmen, C. E., Moore, K. L., Mackay, T. F. C., Johnston, J. S. & Tarone, A. M. 2014. Intrapopulation genome size variation in D. melanogaster reflects life history variation and plasticity. PLoS Genetics 10: e1004522. PMCID: PMC4109859.

Huang, W., Massouras, A., Inoue, Y., Peiffer, J., Ràmia, M., Tarone, A. M., Turlapati, L., Zichner, T., Zhu, D., Lyman, R. F., Magwire, M. M., Blankenburg, K., Carbone, M. A., Chang, K., Ellis, L. L., Fernandez, S., Han, Y., Highnam, G., Hjelmen, C. E., Jack, J. R., Javaid, M., Jayaseelan, J., Kalra, D., Lee, S., Lewis, L., Munidasa, M., Ongeri, F., Patel, S., Perales, L., Perez, A., Pu, L., Rollmann, S. M., Ruth, R., Saada, N., Warner, C., Williams, A., Wu, Y.-Q., Yamamoto, A., Zhang, Y., Zhu, Y., Anholt, R. R. H., Korbel, J. O., Mittelman, D., Muzny, D. M., Gibbs, R. A., Barbadilla, A., Johnston, J. S., Stone, E. A., Richards, S., Deplancke, B. & Mackay, T. F. C. 2014. Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines. Genome Res. 24: 1193-1208. PMCID: PMC4079974.

Mackay, T. F. C. 2014. Epistasis and quantitative traits: Using model organisms to study gene-gene interactions. Nat. Rev. Genetics 15: 22-33. PMCID: PMC3918431

Montgomery, S. L., Huang, W., Anholt, R. R. H., Mackay, T. F. C & Rand, M. D. 2014. Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathways. PLoS ONE 9: e110375. PMCID:
PMC4215868

Morozova, T. V., Mackay, T. F. C. & Anholt, R. R. H. 2014. Genetics and genomics of alcohol
sensitivity. Mol. Genet. Genomics 289: 253-269. PMCID: PMC4037586

Zhou, S., Mackay, T. F. C. & Anholt, R. R. H. 2014. Transcriptional and epigenetic responses to
mating and aging in Drosophila melanogaster. BMC Genomics 15: 927.

Anholt, R. R. H & Mackay, T. F. C. 2015. Dissecting the genetic architecture of behavior in Drosophila melanogaster. Curr. Opin. Behav. Sci. 2: 1-7. PMCID: PMC4507818

Arya, G. H., Magwire, M. M., Huang, W., Serrano-Negron, Y. L., Mackay, T. F. C. & Anholt, R. R. H. 2015. The genetic basis for variation in olfactory behavior in Drosophila melanogaster. Chem. Senses 40: 233-243. PMCID: PMC4398050

Carnes, M. U., Campbell, T. Huang, W. , Butler, D. G., Carbone, M. A., Duncan, L. H., Harbajan, S. V., King, E. M., Peterson, K. R., Weitzel, A., Zhou, S., & Mackay, T. F. C. 2015. The genomic basis of postponed senescence in Drosophila melanogaster. PLoS ONE 10: e0138569. PMCID: PMC4574564

Gaertner, B. E., Ruedi, E. A., McCoy, L. J., Moore, J. M., Wolfner, M. F. & Mackay, T. F. C. 2015. Heritable variation in courtship patterns in Drosophila melanogaster. G3 5: 531-539. PMCID:
PMC4390569

Dembeck, L. M., Böröczky, K., Huang, W., Schal, C., Anholt, R. R. H. & Mackay, T. F. C. 2015. Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. eLife 4: e09861. PMCID: PMC4749392

Dembeck, L. M., Huang, W., Carbone, M. A. & Mackay, T. F. C. 2015. Genetic basis of natural variation in body pigmentation in Drosophila melanogaster. Fly 9: 75-81.

Dembeck, L. M., Huang, W., Magwire, M. M., Lawrence, F., Lyman, R. F. & Mackay, T. F. C. 2015. Genetic architecture of abdominal pigmentation in Drosophila melanogaster. PLoS Genetics PLoS Genet 11: e1005163. PMCID: PMC4416719

Garlapow, M. E., Huang, W., Yarboro, M. T., Peterson, K. R. & Mackay, T. F. C. 2015. Quantitative genetics of food intake in Drosophila melanogaster. PLoS ONE 10: e0138129. PMCID: PMC4574202

Huang, W. Carbone, M. A., Magwire, M. M., Peiffer, J. A., Lyman, R. F., Stone, E. A., Anholt, R. R. H. & Mackay, T. F. C. 2015. Genetic basis of transcriptome diversity in Drosophila melanogaster. PNAS 112: E6010-E6019. PMCID: PMC4640795

Ivanov, D. K., Escott-Price, V., Ziehm, M., Magwire, M. M., Mackay, T. F. C., Partridge, L. & Thornton, J. M. 2015. Longevity GWAS using the Drosophila Genetic Reference Panel. J. Gerontol. A Biol. Sci. Med. Sci. 70: 1470-1478. PMCID: PMC4631106

Morozova, T. V., Huang, W., Pray, V. A., Whitham, T., Anholt, R. R. H. & Mackay, T. F. C. 2015. Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult Drosophila. BMC Genomics 16: 865. PMCID: PMC4624176

Morgante, F., Sørensen, P., Sorensen, D. A., Maltecca, C. & Mackay, T. F. C., 2015. Genetic architecture of micro-environmental plasticity in Drosophila melanogaster. Scientific Reports 5: 9785. PMCID: PMC4421828

Ober, U., Magwire, M. M., Huang, W., Schlather, M., Simianer, H. & Mackay, 2015. Accounting for genetic architecture improves sequence based genomic prediction for a Drosophila fitness trait. PLoS One 10: e0132980. PMCID: PMC4500411

Ramaswami, G., Deng, P., Zhang, R., Carbone, M. A., Mackay, T. F. C. & Li, J. B. 2015. Genetic mapping uncovers cis-regulatory landscape of RNA editing. Nat. Comm. 6: 8194. PMCID:
PMC4573499

Shorter, J. R., Couch, C. R., Huang, W., Carbone, M. A., Peiffer, J., Anholt, R. R. H. & Mackay, T. F. C. 2015. Epistasis and the genetic architecture of Drosophila aggressive behavior. PNAS 112: E3555-E3563. PMCID: PMC4500262

Shorter, J. R., Geisz, M., Özsoy, E., Magwire, M. M., Carbone, M. A. & Mackay, T. F. C. 2015. The effects of royal jelly on fitness traits and gene expression in Drosophila melanogaster. PLoS ONE 10: e0134612. PMCID: PMC4520568

Sorensen, P. S., de los Campos, G., Morgante, F., Mackay, T. F. C. & Sorensen, D. 2015. Genetic control of environmental variation of two quantitative traits of Drosophila melanogaster revealed by whole-genome sequencing. Genetics 201: 487-497. PMCID: PMC4596664

Zwarts, L., Vanden Broeck, L., Cappuyns, E., Ayroles, J. F., Magwire, M. M., Vulsteke, V., Clements, J., Mackay, T. F. C & Callaerts, P. 2015. The genetic basis of natural variation in mushroom body size in Drosophila melanogaster. Nat. Comm. 6: 10115. PMCID: PMC4682101

Carbone, M. A., Yamamoto, A., Huang, W., Lyman, R. A., Meadors, T. B., Yamamoto, R., Anholt, R. R. & Mackay, T. F. C. 2016. Genetic architecture of natural variation in visual senescence in Drosophila. PNAS 113: E6620-E6629. PMCID: PMC5087026

Edwards, S. M., Sørensen, I. F., Sarup, P., Mackay, T. F. C. and Sørensen, P. 2016. Genomic prediction for quantitative traits is improved by mapping variants to Gene Ontology categories in Drosophila melanogaster. Genetics 203: 1871-1883. PMCID: PMC4981283

Friedenberg, S. G., Meurs, K. M. & Mackay, T. F. C. 2016. Evaluation of artificial selection in Standard Poodles using whole genome sequencing. Mamm. Genome 27: 599-609. PMCID: PMC5112125

Gerken, A. R., Mackay, T. F. C. & Morgan, T. J. 2016. Artificial selection on chill-coma recovery time in Drosophila melanogaster: Direct and correlated responses to selection. J. Thermal Biol. 59: 77-85.

He, X., Zhou, S., St. Armour, G. E., Mackay, T. F. C. & Anholt, R. R. H. 2016. Epistatic partners of neurogenic genes modulate Drosophila olfactory behavior. Genes, Brain, Behav. 15: 280-290. PMCID: PMC4841442

Huang, W., Lyman, R. F., Lyman, R., Carbone, M. A., Harbison, S. T., Magwire, M. M and Mackay, T. F. C. 2016. Spontaneous mutation and the origin and maintenance of quantitative genetic variation. eLife 5: e14625

Huang, W. & Mackay, T. F. C. 2016. The genetic architecture of quantitative traits cannot be inferred from variance component analysis. PLoS Genetics 12: e1006421. PMCID: in progress.

Hunter, C. M., Huang, W., Mackay, T. F. C. & Singh, N. D., 2016. The genetic architecture of natural variation in recombination rate in Drosophila melanogaster. PLoS Genetics 12: e1005951. PMCID: PMC4817973

Reidl, C., Oster S., Busto, M., Mackay, T. F. C. & Sokolowski, M. 2016. Natural variability in Drosophila larval and pupal NaCl tolerance. J. Insect. Physiol. 88: 15-23. PMCID: PMC4811728

Shorter, J. R., Dembeck, L. M., Everett, L. J., Morozova, T. V., Arya, G. H., Turlapati, L., St. Amour, G. E., Schal, C., Mackay, T. F. C. & Anholt, R. R. H. 2016. Obp56h modulates mating behavior in Drosophila melanogaster. G3: Genes, Genomes, Genetics, 6: 3335-3342. PMCID: PMC5068952

Vonesch, S. C., Lamparter, D., Mackay, T. F. C., Bergmann, S. & Hafen, E. 2016. Genome-wide analysis reveals novel regulators of growth in Drosophila melanogaster. PLoS Genetics 12: e1005616. PMCID: PMC4709145

Zhou, S., Morozova, T. V., Hussain, Y. N., Luoma, S. E., McCoy, L., Yamamoto, A., Mackay, T. F. C. & Anholt, R. R. H. 2016. The genetic basis for variation in sensitivity to lead toxicity in Drosophila melanogaster. Environ. Health Perspect. 124: 1062-1070. PMCID: PMC4937873

Fochler, S., Morozova, T. V., Davis, M., Gearhart, A., Huang, W., Mackay, T. F. C. & Anholt, R. R. H. 2017. Genetics of alcohol consumption in Drosoophila melanogaster. Genes Brain Behav. 16: 675-685. PMCID: PMC5667673

Garcia, J. F., Carbone, M. A., Mackay, T. F. C. & Anholt, R.R. H. 2017. Regulation of Drosophila lifespan by bellwether promoter alleles. Sci. Reports 7: 4109. PMCID: PMC5482829

Garlapow, M. E., Everett, L. J., Zhou, S., Gearhart, A. W., Fay, K. A., Huang, W., Morozova, T. V., Arya, G. H., Turlapati, L., St. Armour, G., Hussain, Y. N., McAdams, S. E., Fochler, S., & Mackay, T. F. C. 2017. Genetic and genomic response to selection for food consumption in Drosophila melanogaster. Behav. Genet. 42: 227-243. PMCID: PMC5305434

Mackay, T. F. C. & Huang, W. 2018. Charting the genotype-phenotype map: Lessons from the Drosophila melanogaster Genetic Reference Panel. Wiley Interdiscip Rev. Dev. Biol. 7(1). doi: 10.1002/wdev.289. PMCID: PMC5746472

Rohde, P. D., Gaertner, B., Ward, K., Sorenson, P & Mackay, T. F.C. 2017. Genomic analysis of genotype by social environment interaction for Drosophila aggressive behavior. Genetics 206: 1969-1984. PMCID: PMC5560801

Zhou, S., Luoma, S. E., ST. Armour, G. E., Thakkar, E., Mackay, T. F. C. & Anholt, R. R. H. 2017. A Drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure. PLoS Genetics 13: e1006907. PMCID: PMC5544243

Anholt, R. R. H. & Mackay, T. F. C. 2018. The road less traveled: From genotype to phenotype in flies and humans. Mammalian Genome 29: 5-23.

Lstibůrek, M., Bittner, V., Hodge, G. R., Picek, J. & Mackay, T. F. C., 2018. Estimating realized heritability in panmictic populations. Genetics 208: 89-95. PMCID: PMC5753877

Meurs, K. M., Friedenberg, S.G., Williams, B., Keene, B. W., Atkins, C. E., Adin, D., Aona, B., DeFrancesco, T., Tou, S & Mackay, T. F. C. 2018. Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration. Vet J. 232: 16-19.

Morgante, F., Huang, W., Maltecca, C. & Mackay, T. F.C. 2018. Effect of genetic architecture on the prediction accuracy of quantitative traits in samples of unrelated individuals. Heredity 120: 500-514. PMCID: PMC5943287

Morozova, T. V., Hussain, Y., McCoy, L. J., Zhirnov, E. V., Davis, M. R., Pray, V. A., Lyman, R. A., Duncan, L. H., McMillen, A., Jones, A., Mackay, T. F. C. & Anholt, R. R. H. 2018. A Cyclin E centered genetic network contributes to alcohol-induced variation in Drosophila development. G3 8: 2643-2653.

Rohde, P. D., Østergaard, S., Kristensen, T. N., Sørensen, P., Loeschcke, V., Mackay, T. F. C. & Sarup, P. 2018. Functional validation of candidate genes detected by genomic feature models. G3 8: 1659-1668. PMCID: PMC5940157

Harbison, S. T., Kumar, S., Huang, W., McCoy, L. J & Mackay, T. F. C. 2018. Genome wide association study of circadian behavior in Drosophila melanogaster. Behavior Genetics, in press.