Profile
Charles Rice
Biological Sciences
Professor
864-656-2328
Jordan Hall 313 [Lab]
Jordan Hall 313A [Research Laboratory Service]
Long Hall 233 [Office]
Educational Background
Post-doc, VCU Medical Center
Ph.D., William & Mary
M.S., Virginia Commonwealth University
B.S., Virginia Commonwealth University
Research Interests
Role of Inflammation in Chronic Diseases and Cancer Biology, Immunopharmacology & Immunotoxicology, Cellular and Molecular Mechanisms of Immunotoxicity, Mechanisms of Diseases Resistance vs. Susceptibility, Environmental Toxicology & Health, Comparative Immunology, hybridoma and monoclonal antibody technologies.
Research Group (Lab)
Tara Clancy, Ph.D. student
Alyssa Whisel, Ph.D. student
Conner Dicks, M.S student
Courses Taught
Immunology (4140/6140)
Immunotoxicology (8010)
Marine Biology (4170)
Comparative & Veterinary Immunology (8020)
Selected Publications
Representative of interests and collaborations.
Patterson, L.D., Dubansky, B.D., Dubansky, B.H., Stone, S., Kumar, M., Rice, C.D. Generation and Characterization of a Multi-Functional Panel of Monoclonal Antibodies for SARS-CoV-2 Research and Treatment. Viruses 2024, 16, 64. https://doi.org/10.3390/v16010064
Segner, H., Bailey, C.B., Rice, C.D. (in press 2023) Immunotoxicology in fishes, Reference Module in Life Sciences (planned for publication in Encyclopedia of Fish Physiology, Second Edition), Elsevier, 2024, ISBN 9780128096338, https://doi.org/10.1016/B978-0-323-90801-6.00097-5.-
Rice, C.D., Zelikoff, J.T., Segner, H.E. 2024. The Immune System of Fishes: A Target Organ for Toxicity. 2nd Edition. (Chapter 6, pages 191-225 ) In: The Toxicology of Fishes (Kristie Willett and Neel Arulu, Eds). CRC Press. Taylor and Francis Group. Boca Raton, FL USA.
Patterson, L.D., Dubansky, B.D., Dubansky, B.H., Stone, S., Kumar, M., Rice, C.D. 2023. Generation and characterization of a multi-functional panel of monoclonal antibodies for SARS-CoV-2 research and treatment. BioRxiv. In prre-print format online.
Scobie, M.R., Abood, A., Rice, C.D. Differential Transcriptome Responses in Human THP-1 Macrophages Following Exposure to T98G and LN-18 Human Glioblastoma Secretions: A Simplified Bioinformatics Approach to Understanding Patient Glioma-Specific Effects on Tumor-Associated Macrophages. Int. J. Mol. Sci. 2023, 24, 5115. https://doi.org/10.3390/ijms24065115
Anderson, A.L., Dubansky, D.B., Wilson, L.B., Tanguay, R.L., Rice, C.D. (2022). Development and applications of a zebrafish, Danio rerio, CYP1A-targeted monoclonal antibody (CRC4) with reactivity against vertebrate taxa: Evidence for a conserved CYP1A epitope. Toxics . 10:404-418.
LaPlaca, S.B., Rice, C.D., van den Hurk, P. (2022) Chronic toxicity of tire crumb rubber particles to mummichog, Fundulus heteroclitus, in episodic exposure. Science of the Total Environment. https://doi.org/10.1016/j.scitotenv.2022.157447
Alston, B.E, Rainwater, T.R., Parrott, B., Wilkinson, P., Bowden, J.A., Rice, C.D. Quantifying circulating IgY antibody responses against select opportunistic bacterial pathogens and correlations with select body condition factors in wild American alligators, Alligator mississippiensis. 2022. Biology. 11:269-285.
Saphala Dhital, Charles D. Rice, Naren R. Vyavahare (2021). Reversal of elastase-induced abdominal aortic aneurysm following the delivery of nanoparticle-based pentagalloyl glucose (PGG) is associated with reduced inflammatory and immune markers. European Journal of Pharmacology. 2021 Sep 10:174487. doi: 10.1016/j.ejphar.2021.174487
*Anderson, K., Schaefer, A., Rice, C.D. (2021). Quantifying circulating antibody titers against the emerging environmental pathogen, Streptococcus agalactiae, in wild captured bull sharks, spotted eagle rays, bottlenose dolphins, and loggerhead turtles. Fish & Shellfish Immunology Reports. 2:100024.
Silva, R.A., Di Giulio, R.T. and Rice, C.D. (2021), The In Vitro Proinflammatory Properties of Water Accommodated Sediment Extracts from a Creosote Contaminated US Environmental Protection Agency Superfund Site. Environ Toxicol Chem. https://doi.org/10.1002/etc.5001
Baldwin, W.S., Bain, L.J., Di Giulio, R., Kullman, S., Rice, C.D., Ringwood, A.H.., van den Hurk, P. 20th Pollutant Responses in Marine Organisms (PRIMO 20): Global issues and fundamental mechanisms caused by pollutant stress in marine and freshwater organisms. Aquat. Toxicol. 227: 105620. 2020.
Scobie, MR., Houke, HR., Rice, CD. Modulation of glioma-inflammation crosstalk profiles in human glioblastoma cells by Indirubin-3’-(2,3 dihydroxypropyl)-oximether (E804) and 7-Bromoindirubin-3'-oxime (7BIO). Chemico-Biol Interactions. 312: 2019 https://doi.org/10.1016/j.cbi.2019.108816
Rodgers, M.L., Rice, C.D. 2018. Monoclonal antibodies against loggerhead sea turtle, Caretta caretta, IgY isoforms reveal differential contributions to antibody titers and relatedness among other sea turtles. Dev Comp Immunol. 87:12-15.
Rodgers, M.L., Toline, C.A., and Rice, C.D. 2017. Humoral immune responses against select bacterial pathogens in Loggerhead, Caretta caretta, and Kemp’s Ridley, Lepidochelys kempii, sea turtles from the south eastern United States. J Aquat Anim Health (doi: 10.1080/08997659.2017.1391887).
Margiotta, A.L., Bain, L.J., and Rice, C.D. 2017. Expression of the major vault protein and cellular vault particles in fish. Anat Record. 300:1981-1992. DOI: 10.1002/ar.23645.
Dubansky, B., Rice, C.D., Barrois, L.F., Galvez, F. 2017. Biomarkers of aryl-hydrocarbon receptor activity in Gulf killifish (Fundulus grandis) from the northern Gulf of Mexico marsh following the Deepwater Horizon Oil Spill. Special Issue: Ocean Spills and Accidents. Arch Environ Contam Toxicol. July 10, 2017. DOI: 10.1007/s00244-017-0417-6
Fair, P.A., Schaefer, A.M., Houser, D.S., Bossart, G.D., Romano, T.A., Champagne, C.D., Stott, J.L., Rice, C.D., White, N., Reif, J.S. 2017. The Environment as a Driver of Immune and Endocrine Responses in Dolphins (Tursiops truncatus). PLoS ONE 12(5): e0176202. https://doi.org/10.1371/journal.pone.0176202.
Wojdylo, J.V., Vogelbein, W., Bain, L.J., and Rice, C.D. 2016. AHR-related activities in a creosote-adapted population of adult Atlantic killifish, Fundulus heteroclitus, two decades post-EPA Superfund status. Aquat Toxicol, 177:74-85.
Matsebatlela, M.T., Anderson, A.L., Gallicchio, V.S., Elford, H., Rice, C.D. 2015. 3,4-dihydroxy-benzohydroxamic acid (Didox) suppresses pro-inflammatory profiles and oxidative stress in TLR4-activated RAW264.7 murine macrophages. Chem Biol Interact, 25:95-105.
Berg, A.H., Rice, C.D., Rahman, M.S., Dong, J., Thomas, P. 2014. Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: I. Discovery in female Atlantic croaker and evidence ZIP9 mediates testosterone-induced apoptosis of ovarian follicle cells. Endocrinology, 155:4237-4249.
Bossart, G.D., Romano, T.A., Peden-Adams, M.M., Schaefer, A., McCulloch, S., Goldstein, J.D., Rice, C.D., Fair, P.A., Cray, C., Reif, J.S. 2014. Clinicoimmunopathologic findings in Atlantic bottlenose dolphins Tursiops truncatus with positive Chlamydiaceae antibody titers. Dis Aquat Organ, 108:71-81.
Dubanksy, B., Whitehead, A. Miller, J., Rice, C.D., Galvez, F. 2014. Response to comment on “Multi-tissue molecular, genomic, and developmental effects of the Deepwater Horizon oil spill on resident Gulf killifish (Fundulus grandis). Environ Sci Technol, 48:7679-7680.
Dubansky, B., Whitehead, A., Miller, J., Rice, C.D., Galvez, F. 2013. Multi-tissue, genomic, and developmental effects of the Deepwater Horizon oil spill on resident Gulf Killifish, Fundulus grandis. Environ Sci Technol 47:5074 - 5082.
Fair, P.A., Romano, T., Schaefer, A.M., Reif, J.S, ; Bossart, G.D., Houde, M., Muir, D., Adams, J., Rice, C.D.; Hulsey, T.C., Peden-Adams, M. 2013. Associations between perfluoroalkyl compounds and immune and clinical chemistry parameters in highly exposed bottlenose dolphins (Tursiops truncatus). Environ Toxicol Chem, 99:1-12.
Babcock, A.S., Anderson, A.E., and Rice, C.D. 2013. Indirubin-3’-(2,3 dihydroxypropyl)-oximether (E804) is a Potent Modulator of LPS-Stimulated Macrophage Functions. Toxicol Appl Pharmacol, 266:157-166.
Whitehead, A., Dubansky, B., Bodinier, C., Garcia, T., Miles, S., Pilley, C., Raghunathan, V., Roach, J., Walker, N., Walter, R., Rice, C. D., Galvez, F. 2012. Genomic and physiological footprint of the Deep Water Horizon oil spill on resident marsh fishes. Proc Natl Acad Sci USA, 109:20298-20302.
