Profile
Emily E Rosowski
Biological Sciences
Assistant Professor
864-656-5433
Life Sciences Building 155A [Office]
Life Sciences Building 160D [Lab]
Life Sciences Building 166 [Research Laboratory Service]
Educational Background
Ph.D., Biology, Massachusetts Institute of Technology, 2013
B.S., Biology, University of North Carolina at Chapel Hill, 2007
Research Interests
The Rosowski lab investigates host-pathogen interactions and the innate immune response to infections using the larval zebrafish host model. Cutting-edge imaging and genetic methods allow us to define the role of specific cell types and pathways in immune system function. One of our current interests is identifying pathways in macrophages that promote killing of the fungal pathogen Aspergillus fumigatus. We are also interested in how anti-fungal drugs function in vivo and synergize with host immune pathways.
Courses Taught
MICR/BIOL 4140 - Basic Immunology
Selected Publications
## denotes a member of the Rosowski Lab
Glucocorticoids suppress NF-kB-mediated neutrophil control of Aspergillus fumigatus hyphal growth. Thrikawala S##, Anderson M##, Rosowski EE. bioRxiv. doi: 10.1101/2023.12.21.572739.
mSphere of Influence: How host genetics impact microbial pathogenesis and treatment of infectious disease. Rosowski EE. mSphere. 2024 Jan. doi: 10.1128/msphere.00629-23.
Macrophages inhibit extracellular hyphal growth of A. fumigatus through Rac2 GTPase signaling. Tanner CD## and Rosowski EE. Infect Immun. 2024 Jan. doi: 10.1128/iai.00380-23 .
Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish. Thrikawala S##, Niu M, Keller NP, Rosowski EE. PloS Path. 2022 March. doi: 10.1371/journal.ppat.1010040.
Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Houseright RA, Rosowski EE, Lam P-Y, Tauzin SJM, Mulvaney O, Dewey CN, Huttenlocher A. Sci Rep. 2020 Sept. doi: 10.1038/s41598-020-72750-9.
Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions. Thrikawala S## and Rosowski EE. J Vis Exp. 2020 May. doi: 10.3791/61165. Methods.
Illuminating macrophage contributions to host-pathogen interactions in vivo: the power of zebrafish. Rosowski EE. Infect Immun. 2020 June. doi: 10.1128/IAI.00906-19. Review.
Determining macrophage versus neutrophil contributions to innate immunity using larval zebrafish. Rosowski EE. Dis Model Mech. 2020 Jan. doi: 10.1242/dmm.041889. Review.
Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish. Schoen TJ, Rosowski EE, Knox BP, Bennin D, Keller NP, Huttenlocher A. J Cell Sci. 2019 Dec. doi: 10.1242/jcs.236539.
Efficacy of voriconazole against A. fumigatus infection depends on host immune function. Rosowski EE, He J, Huisken J, Huttenlocher, A. Antimicrob Agents Chemother. 2019 Nov. doi: 10.1128/AAC.00917-19.
The Zebrafish as a Model Host for Invasive Fungal Infections. Rosowski EE, Knox BP, Archambault LS, Huttenlocher A, Keller NP, Wheeler RT, Davis JM. J Fungi. 2018 Dec. doi: 10.3390/jof4040136. Review.
Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing. Rosowski EE, Raffa N, Knox BP, Golenberg N, Keller NP, Huttenlocher A. PLoS Pathog. 2018 Aug. doi: 10.1371/journal.ppat.1007229.
Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Rosowski EE, Deng Q, Keller NP, Huttenlocher A. J Immunol. 2016 Dec. doi: 10.4049/jimmunol.1600928.
Neutrophil migration in infection and wound repair: going forward in reverse. de Oliveira S*, Rosowski EE*, Huttenlocher A. Nat Rev Immunol. 2016 May. doi: 10.1038/nri.2016.49. Review.
Toxoplasma gondii Inhibits gamma interferon (IFN-y)- and IFN-B-induced host cell STAT1 transcriptional activity by increasing the association of STAT1 with DNA. Rosowski EE, Nguyen QP, Camejo A, Spooner E, Saeij JP. Infect Immun. 2014 Feb. doi: 10.1128/IAI.01291-13.
Toxoplasma gondii clonal strains all inhibit STAT1 transcriptional activity but polymorphic effectors differentially modulate IFN-gamma induced gene expression and STAT1 phosphorylation. Rosowski EE, Saeij JP. PLoS One. 2012. doi: 10.1371/journal.pone.0051448.
Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. Rosowski EE*, Lu D*, Julien L, Rodda L, Gaiser RA, Jensen KD, Saeij JP. J Exp Med. 2011 Jan. doi: 10.1084/jem.20100717.
