Profile
Emily E Rosowski
Biological Sciences
Assistant Professor
Faculty Scholar, Clemson University School of Health Research
864-656-5433
Life Sciences Building 155A [Office]
Educational Background
Ph.D., Biology, Massachusetts Institute of Technology, 2013
B.S., Biology, University of North Carolina at Chapel Hill, 2007
Research Interests
The Rosowski lab investigates host-pathogen interactions and the innate immune response to infections using the larval zebrafish host model. Cutting-edge imaging and genetic methods allow us to define the role of specific cell types and pathways in immune system function. We are currently interested in how macrophages and neutrophils recognize and kill the fungal pathogen Aspergillus fumigatus.
Courses Taught
MICR/BIOL 4140 - Basic Immunology
MICR/BIOL 4930 - Senior Seminar
MICR 8010 - Concepts in Microbiology II
BIOL 8010 - Concepts of Molecular, Cellular, and Developmental Biology
Selected Publications
## denotes a member of the Rosowski Lab
Aspergillus fumigatus effector crpA orchestrates host prostaglandin signaling to promote fungal virulence. Pinzan CF, Diehl C, de Castro PA, Delbaje E, Rocha P, Marciano CL, da Rosa-Garzon NG, Cabral H, Sprute R, Kolovou A, Vilela AFL, Sorgi CA, Ecoutin A, Berbon M, Loquet A, Freitas-Filho EG, Cunha LD, Thrikawala SU##, Rosowski EE, Dos Reis TF, Goldman GH. mBio. 2025 Oct. doi: 10.1128/mbio.02481-25.
Azole drugs have differential efficacy in varied models of immunosuppression in larval zebrafish hosts . Ayala KE##, Baum S##, Thrikawala SU##, Goins ML##, Anderson M##, Davis C##, Pollock H##, Rosowski EE. Future Microbiology. 2025 Aug. doi: 10.1080/17460913.2025.2539639.
Neutrophil NOX2 Promotes Bacterial Eradication and Regulates NF-kB-Mediated Inflammation via NRF2 Signaling in Urinary Tract Infections. Cotzomi-Ortega I, Rosowski EE, Wang X, Sanchez-Zamora YI, Lopez-Torres JM, Sanchez-Orellana G, Han R, Vásquez-Martínez G, Andrade GM, Ballash G, Cortado H, Li R, Ali Y, Rascon R, Robledo-Avila F, Partida-Sanchez S, Pérez-Campos E, Olofsson-Sahl P, Zepeda-Orozco D, Spencer JD, Becknell B, de Dios Ruiz-Rosado J. Mucosal Immunology. 2025 Apr. doi: 10.1016/j.mucimm.2024.12.010.
Zebrafish use conserved CLR and TLR signaling pathways to respond to fungal PAMPs in zymosan. Glass E##, Robinson SL##, Rosowski EE. Developmental & Comparative Immunology. 2025 Jan. doi: 10.1016/j.dci.2024.105286.
Glucocorticoids suppress NF-kB-mediated neutrophil control of Aspergillus fumigatus hyphal growth. Thrikawala S##, Anderson M##, Rosowski EE. Journal of Immunology. 2024 Oct. doi: 10.4049/jimmunol.2400021.
mSphere of Influence: How host genetics impact microbial pathogenesis and treatment of infectious disease. Rosowski EE. mSphere. 2024 Jan. doi: 10.1128/msphere.00629-23.
Macrophages inhibit extracellular hyphal growth of A. fumigatus through Rac2 GTPase signaling. Tanner CD## and Rosowski EE. Infect Immun. 2024 Jan. doi: 10.1128/iai.00380-23 .
Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish. Thrikawala S##, Niu M, Keller NP, Rosowski EE. PloS Path. 2022 March. doi: 10.1371/journal.ppat.1010040.
Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Houseright RA, Rosowski EE, Lam P-Y, Tauzin SJM, Mulvaney O, Dewey CN, Huttenlocher A. Sci Rep. 2020 Sept. doi: 10.1038/s41598-020-72750-9.
Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions. Thrikawala S## and Rosowski EE. J Vis Exp. 2020 May. doi: 10.3791/61165. Methods.
Illuminating macrophage contributions to host-pathogen interactions in vivo: the power of zebrafish. Rosowski EE. Infect Immun. 2020 June. doi: 10.1128/IAI.00906-19. Review.
Determining macrophage versus neutrophil contributions to innate immunity using larval zebrafish. Rosowski EE. Dis Model Mech. 2020 Jan. doi: 10.1242/dmm.041889. Review.
Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish. Schoen TJ, Rosowski EE, Knox BP, Bennin D, Keller NP, Huttenlocher A. J Cell Sci. 2019 Dec. doi: 10.1242/jcs.236539.
Efficacy of voriconazole against A. fumigatus infection depends on host immune function. Rosowski EE, He J, Huisken J, Huttenlocher, A. Antimicrob Agents Chemother. 2019 Nov. doi: 10.1128/AAC.00917-19.
The Zebrafish as a Model Host for Invasive Fungal Infections. Rosowski EE, Knox BP, Archambault LS, Huttenlocher A, Keller NP, Wheeler RT, Davis JM. J Fungi. 2018 Dec. doi: 10.3390/jof4040136. Review.
Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing. Rosowski EE, Raffa N, Knox BP, Golenberg N, Keller NP, Huttenlocher A. PLoS Pathog. 2018 Aug. doi: 10.1371/journal.ppat.1007229.
Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Rosowski EE, Deng Q, Keller NP, Huttenlocher A. J Immunol. 2016 Dec. doi: 10.4049/jimmunol.1600928.
Neutrophil migration in infection and wound repair: going forward in reverse. de Oliveira S*, Rosowski EE*, Huttenlocher A. Nat Rev Immunol. 2016 May. doi: 10.1038/nri.2016.49. Review.
