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Contact Information

P: 864-656-2328

Campus Location

132 Long Hall, Clemson, SC 29634


Monday - Friday:
8 a.m. - 4:30 p.m.


Profile Photo

Lisa Bain

Biological Sciences


Jordan Hall 300 [Lab]
Long Hall 239 [Office]

Educational Background

Ph.D., Toxicology, North Carolina State University
B.S., Environmental Health Sciences, University of Georgia

Profile/About Me

Understanding the mechanisms by which chemicals found in drinking water impact development and cell fate determination

Research Interests

Research in the Bain laboratory focuses on the mechanisms by which cells respond to toxicants found in food and drinking water, such as arsenic, pharmaceuticals, and novel synthetic organics. We are currently investigating how these compounds delay cellular differentiation and development. For example, arsenic is a contaminant in drinking water in many parts of the world and has been found at appreciable levels in rice and other crops. Arsenic readily crosses the placental barrier and exposure is correlated with adverse developmental outcomes such as stillbirths, low birth weight, delays in the use of musculature, and altered neuronal function.

We are examining drinking water chemicals' effects on development and cellular differentiation in several different stem cell lines (induced pluripotent stem cells, mesenchymal stem cells, neuronal progenitor cells), in rodents, and in zebrafish embryos using a variety of molecular (microarrays, qPCR, ChiP), epigenetic (miR expression, histone modification) biochemical and immunohistochemical techniques. The goal is to understand if early exposure results in long-term functional effects.

Courses Taught

ETOX 6300 - Toxicology

BIOL 4610 - Cell Biology

BIOL 4930 - Senior Seminar

Selected Publications

Perego CM, McMichael BM, McMurry NR, Ventrello SW, and Bain LJ (2023) Arsenic impairs differentiation of human induced pluripotent stem cells into cholinergic motor neurons, Toxics, 18, 644.

Perego CM, McMichael BM, and Bain LJ (2023) Arsenic impairs stem cell differentiation via the Hippo signaling pathway, Toxicology Research, 2023, 1-14.

Duong T-B, Dwivedi R* and Bain LJ (2023) 2,4-di-tert-butylphenol exposure impairs osteogenic differentiation, Toxicology and Applied Pharmacology, 461,116386. doi: 10.1016/j.taap.2023.116386

Kellett MP, Jatko JT, Darling CL, Ventrello SW and Bain LJ (2022) Arsenic exposure impairs intestinal stromal cells, Toxicology Letters, 361, 56-63. doi: 10.1016/j.toxlet.2022.03.006

Jatko JT, Darling CL, Kellett MP, and Bain LJ (2021) Arsenic exposure in drinking water reduces Lgr5 and secretory cell marker gene expression in mouse intestines, Toxicology and Applied Pharmacology, 422:115561.

McMichael BM, Perego CM, Darling CL, Perry RL, Coleman SC, and Bain LJ (2020) Chronic arsenic exposure impairs differentiation in P19 mouse embryonic stem cells, Journal of Applied Toxicology, online.

Baldwin WS and Bain LJ (2020) PRIMO 20 – 20th International Symposium of Pollutant Responses in Marine Organisms: Key issues and mechanisms in marine and freshwater toxicology, Marine Environmental Research, 126, 105111. doi: 10.1016/j.marenvres.2020.105111

Baldwin WS, Bain LJ, Di Guilio R, Kullman S, Rice CD, Ringwood AH, and van den Hurk P (2020) 20th Pollutant Responses in Marine Organisms (PRIMO 20): Global issues and fundamental mechanisms caused by pollutant stress in marine and freshwater organisms, Aquatic Toxicology, 277, 105620.

Szymkowicz DB, Sims KC, Schwendinger KL, Tatnall CM, Powell RR, Bruce TF, Bridges WC, and Bain LJ (2019) Embryonic arsenic impairs olfactory sensory neuron differentiation and function into adulthood, Toxicology, 420:73-84.

Sims KC, Schwendinger KL, Szymkowicz DB, Swetenburg JR, and Bain LJ (2019) Embryonic arsenic reduces intestinal proliferation and alters hepatic IGF expression in killifish (Fundulus heteroclitus), Journal of Toxicology and Environmental Health part A, 82:142-156.

Szymkowicz DB, Schwendinger KL, Tatnall CM, Swetenburg JR, and Bain LJ (2018) Embryonic-only arsenic exposure alters skeletal muscle satellite cell function in killifish (Fundulus heteroclitus), Aquatic Toxicology, 198:276-286.

Liu J-T and Bain LJ (2018) Arsenic induces members of the mmu-miR-466-669 cluster which reduces NeuroD1 expression, Toxicological Sciences, 162:64-78.


Professional organizations and scientific meetings typically attending by laboratory members include the Society of Toxicology, the Society of Environmental Toxicology and Chemistry, and Pollutant Responses in Marine Organisms (PRIMO)


Support for reducing the amount of arsenic in apple juice
Grant to study effects of arsenic on intestinal stem cells
Clemson scientist receives $367K grant to trace how arsenic disrupts developing cells
Using killifish as a model for developmental toxicity

Contact Information

P: 864-656-2328

Campus Location

132 Long Hall, Clemson, SC 29634


Monday - Friday:
8 a.m. - 4:30 p.m.