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Biological Sciences Profiles

David Feliciano

Associate Professor
Biological Sciences Department

Office: 326
Fax: Jordan

Personal Website:

 Educational Background

State University of New York at Buffalo PhD

Yale University Postdoctorate

 Courses Taught

Cell Biology

 Research Interests

The Feliciano laboratory studies neurogenesis, the process of producing neurons from neural stem cells. The laboratory is focused on embryonic development of the cerebral cortex which is the neuroanatomical site of numerous neuropathological states. The laboratory also uses perinatal neurogenic regions, mainly the subventricular zone, to study cellular and molecular regulation of neurogenesis. The hope is that these studies illuminate novel therapeutic strategies for neurodevelopmental disorders including Tuberous Sclerosis Complex, malformations of cortical development, and epilepsy.


21.Neckles, V.N., Morton, M.C., Holmberg, J.C., Sokolov, A.M., Nottoli, T., Liu, D., and Feliciano, D.M. (2019) A transgenic inducible GFP extracellular-vesicle reporter (TIGER) mouse illuminates neonatal cortical astrocytes as a source of immunomodulatory extracellular vesicles. Scientific Reports

20. Mary C. Morton, Victoria N. Neckles, Caitlin M. Seluzicki, Jennie C. Holmberg, David M. Feliciano (2018) Neonatal Subventricular Zone Neural Stem Cells Release Extracellular Vesicles that Act as a Microglial Morphogen. Cell Reports, Apr 3​

19. Aidan M. Sokolov, Caitlin M. Seluzicki, Mary C. Morton, David M. Feliciano, (2018) Dendrite Growth and the Effect of Ectopic Rheb Expression on Cortical Neurons. Neuroscience Letters, Feb 12;671:140-147. doi: 10.1016

18. Feliciano, D. M., Bordey, A., and Bonfanti, L. (2016) Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain. Cold Spring Harbor perspectives in biology 7, a018846

17. Mahoney C, Feliciano DM, Bordey A, Hartman NW. Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice. Neurosci Lett. 2016 Feb 12;614:112-8. doi: 10.1016/j.neulet.2015.12.042. Epub 2016 Jan 23.

16. Zhang, L., Feliciano, D. M., Huang, T., Zhang, S., and Bordey, A. (2016) Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis. Neuroscience letters 612, 43-47

15. Morton, M., Feliciano, D.M. (2015) Neurovesicles in Brain Development. Cell Mol Neurobiol. 2016 Mar 18

​14. Zhang, L., Bartley, C. M., Gong, X., Hsieh, L. S., Lin, T. V., Feliciano, D. M.,
and Bordey, A. (2014) MEK-ERK1/2-Dependent FLNA Overexpression Promotes Abnormal Dendritic Patterning in Tuberous Sclerosis Independent of mTOR. Neuron 84, 78-91

13. Tietje, A., Maron, K. N., Wei, Y., and Feliciano, D. M. (2014) Cerebrospinal Fluid Extracellular Vesicles Undergo Age Dependent Declines and Contain Known and Novel Non-coding RNAs. PloS one 9, e113116

​12. Feliciano, D. M., Zhang, S., Nasrallah, C. M., Lisgo, S. N., and Bordey, A. (2014) Embryonic cerebrospinal fluid nanovesicles carry evolutionarily conserved molecules and promote neural stem cell amplification. PloS one 9, e88810

​11. Hartman, N. W., Lin, T. V., Zhang, L., Paquelet, G. E., Feliciano, D. M., and Bordey, A. (2013) mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo. Cell Reports 5, 433-444

​10. Lafourcade, C. A., Lin, T. V., Feliciano, D. M., Zhang, L., Hsieh, L. S., and Bordey, A. (2013) Rheb activation in subventricular zone progenitors leads to heterotopia, ectopic neuronal differentiation, and rapamycin-sensitive olfactory micronodules and dendrite hypertrophy of newborn neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 33, 2419-2431

​9. Feliciano, D. M., Zhang, S., Quon, J. L., and Bordey, A. (2013) Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex. Human molecular genetics 22, 1725-1734

​8. Feliciano, D. M., Lin, T. V., Hartman, N. W., Bartley, C. M., Kubera, C., Hsieh, L., Lafourcade, C., O'Keefe, R. A., and Bordey, A. (2013) A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience****

​7. Feliciano, D. M., Lafourcade, C. A., and Bordey, A. (2013) Neonatal subventricular zone electroporation. Journal of visualized experiments : JoVE

​6. Feliciano, D. M., and Bordey, A. (2013) Newborn cortical neurons: only for neonates? Trends in neurosciences 36, 51-61

​5. Karacosta, L. G., Foster, B. A., Azabdaftari, G., Feliciano, D. M., and Edelman, A. M. (2012) A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression. The Journal of biological chemistry 287, 24832-24843 ***

​4. Feliciano, D. M., Quon, J. L., Su, T., Taylor, M. M., and Bordey, A. (2012) Postnatal neurogenesis generates heterotopias, olfactory micronodules and cortical infiltration following single-cell Tsc1 deletion. Human molecular genetics 21, 799-81

3. Feliciano, D. M., Su, T., Lopez, J., Platel, J. C., and Bordey, A. (2011) Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice. The Journal of clinical investigation 121, 1596-1607 *, **

​2. Feliciano, D., and Bordey, A. (2011) [Mouse model of tuberous sclerosis complex]. Medicine sciences : M/S 27, 328-330

​1. Feliciano, D. M., and Edelman, A. M. (2009) Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells. The Journal of biological chemistry 284, 26466-26481

​Books and Monographs
David M. Feliciano, Angelique Bordey, and Luca Bonfanti: Non Canonical Sites of Adult Neurogenesis in the Mammalian Brain
Adult Neurogenesis, (Cold Spring Harbor Monograph) 1 Bungtown Road, Cold Spring Harbor, NY 11724. 2nd Edition, Edited by Fred H. Gage, The Salk Institute for Biological Studies, San Diego, California; Gerd Kempermann, Center for Regenerative Therapies, Dresden, Germany; Hongjun Song, Johns Hopkins School of Medicine, Baltimore, Maryland


Neural Stem Cell-Microglia News
Tuberous Sclerosis Complex Grant
Tuberous Sclerosis Complex News
Exosome News