Yanzhang Wei


Contact Information

Office: 055B Life Science Facility
Lab:    060D Life Science Facility
Phone: 864-656-7393
Fax:     864-656-0435
Email: ywei@clemson.edu


  • Ph.D. Molecular and Cellular Biology, Ohio University, 1996
  • M.S. Genetics, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China, 1985
  • B.S. Biology, Shenyang Normal University, Shenyang, China, 1982 

Research Interests

  • Dendritic cell and natural killer cell mediated cancer immunotherapy
  • Cancer gene therapy
  • Natural product mediated cancer therapy
  • Novel approaches for targeted cancer therapy 

Selected Publications

  1. Li J, Chang LC, Wall W, Wong DKW, Yu X,  and Wei Y. Antitumor activity of fermented noni exudates and its fractions. Mol Clin Onco 1: 161-164, 2013.
  2. Zhu L, Zhao Z, Wei Y, Marcotte W Jr, Wagner TE, Yu X. An IL-12/Shh-C domain fusion protein-based IL-12 autocrine loop for sustained natural killer cell activation. Int J Oncol. 2012 Aug;41(2):661-9. doi: 10.3892/ijo.2012.1466.
  3. Zhao Z, Holle L, Song W, Wei Y, Wagner TE, Yu X. Antitumor and anti-angiogenic activities of Scutellaria barbata extracts in vitro are partially mediated by inhibition of Akt/protein kinase B. Mol Med Report. 2012 Mar;5(3):788-92.
  4. Kim JY, Ballato J, Foy P, Hawkins T, Wei Y, Li J, Kim SO. Apoptosis experiments of cultured tumor cells treated with 200-μm-sized flexible microplasma jet. IEEE Transactions on Plasma Science. 39 (11): 2974-2975 (2011).
  5. Kim JY, Ballato J, Foy P, Hawkins T, Wei Y, Li J, Kim SO. Apoptosis of lung carcinoma cells induced by a flexible optical fiber-based cold microplasma. Biosens Bioelectron. 2011 Oct 15;28(1):333-338.
  6. Kim JY, Wei Y, Li J, Foy P, Hawkins T, Ballato J, Kim SO. Apoptosis of Lung Carcinoma Cells Induced by Flexible Cold Microplasma Jets for Improvement of Targeting. Small, 7: 2290 (2011).
  7. Nishijima KA, Wall MM, Chang LC, Wei Y, Wong DKW. First report of association of Mucor circinelloides on Noni (Morinda citrifolia) in Hawaii. Plant Disease, 95: 00, (2011).
  8. Kim JY, Wei Y, Li J, Kim SO. 15-μm-sized single-cellular-level and cell-manipulatable microplasma jet in cancer therapies. Biosens Bioelectron. 26: 555-9 (2010).
  9. Kotturi, HSR, Li, J, Branham-O’Connor, M., Yu, X., Wagner, TE, Wei, Y. In vitro and in vivo delivery of a novel anticancer fusion protein MULT1E/FasTI via adenoviral vectors. Cancer Gene Therapy, 17: 164-170 (2010).
  10. Kim, JY, Kim, SO., Wei, Y., Li, J. A flexible cold microplasma jet   using biocompatible dielectric tubes for cancer therapy. Applies Physics Letter, 96: 203701 (2010).
  11. Kim, JY, Ballato, J., Foy, P., Hawkins, T., Wei, Y., Li, J., Kim, SO. Single-Cell-Level Cancer Therapy Using a Hollow Optical Fiber-Based Microplasma. Small, 6: 1474-8 (2010).
  12. Branham-O’Connor, M., Li, L., Kotturi, HSR, Yu, X., Wagner, TE, Wei, Y. Fusion induced reversal of dendritic cell maturation: an altered expression of inflammatory chemokine and chemokine receptors in dendritomas. Oncology Reports, 23: 545-550 (2010).
  13. Zhang, X., Thorne, RE., Wagner, TE, Wei, Y. Regulatory T cells and cancer therapy: an old story with a new hope. Current Cancer Therapy Reviews, 6: 34-40 (2010).
  14. Ma, Z., Yun, JX, Wei Y., Burg, KJK, Yuan, X., Gao, BZ. Laser guidance-based cell detection. Proc. SPIE 7400: N1-N11 (2009).
  15. Holle, L., Song, W., Holle, E., Wei, Y., Li, J., Wagner, TE, Yu, X. In vitro-and in vivo-targeted tumor lysis by an MMP2 cleavable melittin-LAP fusion protein. International Journal of Oncology, 35: 829-835 (2009).
  16. Wei, Y., Li, J., Wagner, TE. Dendritoma Vaccine for cancer. Current Cancer Therapy Reviews, 5: 134-141 (2009).
  17. Fang, L., Zhang, X., Miao, J., Zhao, F., Yang, K., Zhuang, R., Bujard, H., Wei, Y., Yang, A., Chen, L., Jin, B. Expression of CD226 Antagonizes Apoptotic Cell Death in Murine Thymocytes. Journal of Immunology, 182 (9): 5453-5460 (2009)
  18. Lolle, L., Song, W., Holle, E., Nilsson, J., Wei, Y., Li, J., Wagner, TE, Yu, X. In vivo targeted killing of prostate tumor cells by a synthetic amoebapore helix 3 peptide modified with two γ-linked glutamate residues at the COOH terminus. Molecular Medicine Reports, 2:399-403 (2009).
  19. Zhang, X., Li, J., Wong, D., Wagner, TE, Wei Y. Fermented Noni Exudates (fNE)-treated dendritic cells directly stimulate B lymphocyte proliferation and differentiation. Oncology Reports, 21:1147-1152 (2009).
  20. Li, J., King, AV., Stickel, SL., Burgin, KE., Zhang, Z., Thomas E. Wagner, TE., Wei, Y. Whole Tumor Cell Vaccine with Irradiated S180 Cells as Adjuvant. Vaccine, 27:558-564 (2009).
  21. Craig, DH, Gayer, CP., Schaubert, KL, Wei, Y., Li, J., Basson, MD. Increased extracellular pressure enhances cancer cell integrin binding affinity through phosphorylation of β1-integrin at threonine 788/789. Am J Physiol Cell Physiol 296: C193-204 (2009).
  22. Ma, Z., Burg, KJL, Wei, Y., Yuan, XL, Peng, X., Gao, BZ. Laser-Guidance Detection of Cells with Single-Gene Modification. Applied Physics Letter, 92: 2139021-2139023 (2008).
  23. Li, J., Stickel, S., Bouton-Verville, H., Burgin, KE, Yu, X., Wong, DKW, Wagner, TE, Wei, Y. Fermented Noni Exudates (fNE): A Mediator between Immune System and Anti-Tumor Activity. Oncology Reports, 20: 1505-1510 (2008).
  24. Kotturi, HS., Li, J., Branham-O’Connor, M., Yu, X., Wagner, TE.,  Wei, Y. Tumor cells expressing a fusion protein of MULT1 and Fas are rejected in vivo by apoptosis and NK cell activation. Gene Therapy, 15:1302-1310 (2008).
  25. Y. Wei, J. J. Stephenson, J. Li, K. E. Burgin, H. Bouton-Verville, S. Jakubchak, L. M. Holmes, K. Meyer, J. Martin, S. D. Trocha, T. E. Wagner. A phase II clinical study of dendritoma vaccination combined with low dose interleukin-2 in advanced melanoma patients. Journal of Clinical Oncology, 25:130S (2007).
  26. Wei, Y., Sticca, RP., Li, J., Holmes, LM., Burgin, KE., Jakubchak, S., Bouton-Verville, H., Williamson, J., Meyer, K., Evans, L., Martin, J., Stephenson, JJ., Trocha, S., Smith, S., Wagner, TE. Combined Treatment of Dendritoma Vaccine and Low Dose Interleukin-2 in Stage IV Renal Cell Carcinoma Patients Induced Clinical Response: A Pilot Study. Oncology Report, 18:665-671 (2007).
  27. Li, J., Theofanous, L., Stickel, S., Bouton-Verville, H., Burgin, KE, Jakubchak, S., Wagner, TE, Wei, Y. Transfer of In Vitro Expanded T Lymphocytes After Activation with Dendritomas Prolonged Survival of Mice Challenged with EL4 Tumor Cells. International Journal of Oncology, 31: 193-197 (2007).

Graduate Students

  • Ashlee Tietje, Ph.D.
  • Xi Yang, Ph.D.

Recent Courses

  • MICR/BIOL/AVS 414/H414/614, Basic Immunology
  • BIOL 871, Tumor Biology and Cancer Therapeutics
  • BIOL 491/491H, Undergraduate student research
  • BIOL 494/494H, Undergraduate student creative inquiry research
  • BIOL 871, Advanced Cell and Functional Biology (Team member)
  • MICR 617, Cancer and Aging (Guest lecturer)

Professional Affiliations

  • American Association for Advancement of Science
  • American Association for Cancer Research
  • Oncology Research Institute, Greenville Hospital System, Assistant Director