Genetics and Biochemistry Department
Office: 051A Life Sciences Facility
Ph.D. Human Genetics
University of Michigan 2010
Central Michigan University B.S.
Our research focuses on DNA repair mechanisms and how aberrant repair results in increased genome instability and a predisposition to cancer. The projects in the lab focus on the homologous recombination (HR) pathway of DNA double strand break repair in mammalian cells. HR factors are not only required for repair of double strand breaks, but play critical roles in protecting stalled replication forks. Using a combination of genetic, cellular and biochemical approaches, our lab focuses on generating targeted mutations in HR factors to gain mechanistic insight into the role of HR proteins in replication and repair.
Tsabar M, Mason JM, Chan YL, Bishop DK, Haber JE (2015). Caffeine inhibits gene conversion by displacing Rad51 from ssDNA. Nucleic Acids Research. 43(14): 6902-18. PMID: 26019181.
Tsabar M, Eapen V, Mason JM, Memisoglu G, Waterman D, Long M, Bishop DK, Haber JE (2015). Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2. Nucleic Acids Research. 43(14): 6889-901. PMID: 26019182.
Mason JM, Dusad K, Wright WD, Grubb J, Budke B, Heyer WD, Connell PP, Weichselbaum RR, Bishop DK (2015). RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells. Nucleic Acids Research. 43(6): 3180-96. PMID: 25765654.
Mason JM*, Logan HL*, Budke B, Wu M, Pawlowski M, Weichselbaum RR, Kozikowski AP, Bishop DK, Connell PP (2014). The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors. Cancer Research. 74(13): 3546-55. PMID: 24753642. *co-first author.
Mason JM*, Das I*, Arlt M, Patel N, Kraftson S, Glover T, Sekiguchi J (2013). The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability. Human Molecular Genetics. 22(24): 4901-13. PMID: 23863462. *co-first author.
Mason JM and Sekiguchi J (2011). SNM1B/APOLLO functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks. Human Molecular Genetics. 20(13): 2549-59. PMID: 21478198.